Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.56 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10189564 | 0.84 | DGAT1 (0.47) | DGAT1SOAT1KCNH2FAAHCHRM2 | |
| SCHEMBL902705 | 0.76 | DGAT1 (0.55) | DGAT1SOAT1KCNH2ADORA2AFAAH | |
| SCHEMBL10189665 | 0.75 | DGAT1 (0.40) | DGAT1SOAT1ALDH1A1 | |
| SCHEMBL902547 | 0.74 | DGAT1 (0.78) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL901002 | 0.72 | DGAT1 (0.74) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902462 | 0.72 | DGAT1 (0.73) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902382 | 0.71 | DGAT1 (0.72) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902748 | 0.70 | DGAT1 (0.55) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902304 | 0.70 | DGAT1 (0.76) | DGAT1SOAT1ALDH1A1 | |
| SCHEMBL902557 | 0.69 | DGAT1 (0.86) | DGAT1SOAT1KCNH2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |