Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535703 | 0.82 | PLK1 (0.61) | PLK1CSNK2A1PLK3HIF1ADRD4 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.80 | PLK1 (0.59) | PLK1CSNK2A1PLK3HIF1ADRD4 | |
| SCHEMBL2709347 | 0.74 | SIGMAR1 (0.47) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL9533936 | 0.74 | PLK1 (0.74) | PLK1CSNK2A1PLK3HIF1ADRD4 | |
| SCHEMBL9211095 | 0.74 | PLK1 (0.49) | PLK1CSNK2A1PLK3HIF1ADRD4 | |
| Hydrochloric Acid SCHEMBL9216167 | 0.73 | PLK1 (0.47) | PLK1CSNK2A1PLK3HIF1ADRD4 | |
| Dihydrophenanthrene SCHEMBL30297028 | 0.71 | CES1 (0.68) | SETD7CES1SRD5A1KDM4EALDH1A1 | |
| Dihydrophenanthrene SCHEMBL155991 | 0.71 | CES1 (0.68) | SETD7CES1SRD5A1KDM4EALDH1A1 | |
| Dihydrophenanthrene SCHEMBL29404495 | 0.71 | CES1 (0.68) | SETD7CES1SRD5A1KDM4EALDH1A1 | |
| SCHEMBL22980483 | 0.69 | PLK1 (0.79) | PLK1CSNK2A1PLK3HIF1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274674-A1 | PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES | PTC THERAPEUTICS, INC. (US) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274674-A1 | PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES | UPF1, RNMT, VHL | PLK1 1329/4885CSNK2A1 560/4885PLK3 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.