Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10195780 | 0.83 | ESRRA (0.44) | WDR5NPC1TSHRALOX5APFEN1 | |
| SCHEMBL10194732 | 0.77 | ESRRA (0.44) | WDR5NPC1TSHRRAB9AESRRA | |
| SCHEMBL17850412 | 0.77 | ESRRA (0.48) | WDR5SMN1; SMN2ESRRAGPR119 | |
| SCHEMBL17850414 | 0.73 | HPGD (0.40) | HPGDWDR5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10194954 | 0.72 | FLT3 (0.50) | PIK3CATNKSHPGDNPC1TP53 | |
| SCHEMBL8280049 | 0.70 | PKM (0.57) | HPGDTSHRMEN1KMT2A | |
| SCHEMBL11976981 | 0.68 | PHGDH (0.58) | HPGDTSHRMEN1KMT2A | |
| (2-Aminophenyl)(Morpholino)Methanone SCHEMBL30988542 | 0.68 | GAA (0.62) | HPGDTP53TSHRSMN1; SMN2MEN1 | |
| (2-Aminophenyl)(Morpholino)Methanone SCHEMBL11446442 | 0.68 | GAA (0.62) | HPGDTP53TSHRSMN1; SMN2MEN1 | |
| SCHEMBL10194913 | 0.67 | ESRRA (0.49) | ESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |