Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194916 | 0.85 | IDO1 (0.42) | HPGDSMN1; SMN2ALDH1A1IDO1TDO2 | |
| SCHEMBL10195752 | 0.81 | GPR119 (0.40) | HPGDSMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL17850419 | 0.80 | WDR5 (0.37) | HPGDALDH1A1WDR5JAK2 | |
| SCHEMBL10195458 | 0.78 | DRD2 (0.42) | HPGDSMN1; SMN2ALDH1A1HTTIDO1 | |
| SCHEMBL10195780 | 0.73 | ESRRA (0.44) | ALDH1A1MAPTHTTWDR5ESRRA | |
| SCHEMBL10194732 | 0.73 | ESRRA (0.44) | ALDH1A1KDM4EMAPTHTTWDR5 | |
| SCHEMBL10195446 | 0.73 | PIK3CA (0.42) | HPGDSMN1; SMN2WDR5ESRRANPC1 | |
| SCHEMBL10194789 | 0.71 | MAPK10 (0.47) | HPGDSMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL10194698 | 0.71 | MAPK10 (0.49) | HPGDSMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL17850412 | 0.71 | ESRRA (0.48) | SMN1; SMN2WDR5ESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |