Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 11/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10195780 | 0.88 | ESRRA (0.44) | ESRRAWDR5 | |
| SCHEMBL10194732 | 0.86 | ESRRA (0.44) | ESRRAWDR5 | |
| SCHEMBL10195446 | 0.77 | PIK3CA (0.42) | ESRRAGPR119WDR5SMN1; SMN2 | |
| SCHEMBL17850437 | 0.74 | ESRRA (0.47) | ESRRAGPR119NOTUM | |
| SCHEMBL10194950 | 0.74 | MAPK10 (0.44) | GPR119 | |
| SCHEMBL17850414 | 0.71 | HPGD (0.40) | ESRRAWDR5SMN1; SMN2 | |
| SCHEMBL22834181 | 0.71 | GPR119 (0.41) | GPR119NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL10194913 | 0.71 | ESRRA (0.49) | ESRRA | |
| SCHEMBL4287349 | 0.71 | EPHX2 (0.48) | SMN1; SMN2 | |
| SCHEMBL10195456 | 0.69 | GPR119 (0.37) | GPR119NOTUMRXRAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |