Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | BCR | P11274 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194950 | 0.83 | MAPK10 (0.44) | GPR119LRRK2MAPK8MAPK10ALDH1A1 | |
| SCHEMBL22834181 | 0.74 | GPR119 (0.41) | GPR119RXRAGRIN1GRIN2BNOTUM | |
| SCHEMBL10194693 | 0.72 | LRRK2 (0.46) | LRRK2MAPK8MAPK10ALDH1A1L3MBTL1 | |
| SCHEMBL10194888 | 0.72 | MAPK10 (0.43) | LRRK2MAPK8MAPK10ALDH1A1TSHR | |
| SCHEMBL17850433 | 0.71 | MAPK14 (0.36) | LRRK2MAPK10 | |
| SCHEMBL17850412 | 0.69 | ESRRA (0.48) | GPR119RXRAGRIN1GRIN2BNOTUM | |
| SCHEMBL10194754 | 0.69 | JAK2 (0.47) | EPHX2LRRK2MAPK8MAPK10 | |
| SCHEMBL10195054 | 0.69 | MAPK1 (0.46) | EPHX2MAPK8MAPK10 | |
| SCHEMBL22845788 | 0.69 | P2RY14 (0.40) | GPR119NOTUMTSHR | |
| SCHEMBL29530740 | 0.69 | P2RY14 (0.40) | GPR119NOTUMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |