SCHEMBL10195708

SCHEMBL10195708

CC[C@@H](C[C@@H](CC)c1ccc(C)cc1)NC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
ALDH1A1 P00352 2/20 0.36
LMNA P02545 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
SLC6A4 P31645 1/20 0.35
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
CHRNA7 P36544 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
NR3C1 P04150 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3989199 0.77 ADRA2A (0.48) HDAC8HDAC6ALDH1A1LMNASMN1; SMN2
SCHEMBL19123060 0.76 ACHE (0.40) HDAC8HDAC6ALDH1A1LMNASMN1; SMN2
SCHEMBL29345484 0.75 ADRA2A (0.40) HDAC8HDAC6ALDH1A1LMNASMN1; SMN2
SCHEMBL22783193 0.71 SLC6A4 (0.65) SLC6A4NR3C1PGRNR3C2HTR1B
SCHEMBL19446442 0.70 ESR1 (0.38) HDAC8HDAC6ALDH1A1LMNASMN1; SMN2
SCHEMBL19803213 0.70 ADRA2A (0.42) HDAC8HDAC6ALDH1A1LMNASMN1; SMN2
SCHEMBL9397889 0.70 ALDH1A1 (0.44) HDAC8HDAC6ALDH1A1LMNASMN1; SMN2
SCHEMBL14452548 0.70 ALDH1A1 (0.53) ALDH1A1LMNASMN1; SMN2CHRNA7MEN1
SCHEMBL18714383 0.70 ESR1 (0.46) HDAC8HDAC6ALDH1A1LMNASMN1; SMN2
SCHEMBL16979038 0.70 ESR1 (0.44) HDAC8HDAC6ALDH1A1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012084704-A1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO S.A. (CH) 2012-06-28 WO disclosed