Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSF1 | Q00613 | 11/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | RAF1 | P04049 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 1.00 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 1.00 |
| ▸ | CASP1 | P29466 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | GALK1 | P51570 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | CASP7 | P55210 | 2/20 | 1.00 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472208 | 0.85 | RAF1 (0.74) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL3293964 | 0.80 | RAF1 (1.00) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL20442137 | 0.80 | TDP2 (0.74) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL15032582 | 0.78 | RAF1 (0.73) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL15034885 | 0.78 | TDP2 (0.81) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL15032584 | 0.76 | KDM4E (0.70) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL20442145 | 0.76 | TDP2 (0.74) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL14019967 | 0.76 | TDP2 (1.00) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL20442139 | 0.75 | TDP2 (0.74) | HSF1KDM4EMEN1ALDH1A1RAF1 | |
| SCHEMBL15032577 | 0.75 | RAF1 (0.76) | HSF1KDM4EMEN1ALDH1A1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210113570-A1 | INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION | INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER | 2021-04-22 | — | — | US | disclosed |
| US-10888564-B2 | Inhibitors of HIV-1 integrase multimerization | INSTITUTE FOR CANCER RESEARCH (US) | 2021-01-12 | — | — | US | disclosed |
| WO-2018140762-A1 | INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION | INSTITUTE FOR CANCER RESEARCH d.b.a THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (US) | 2018-08-02 | — | — | WO | disclosed |
| US-9073941-B2 | Compounds and methods for treating tuberculosis infection | ACADEMIA SINICA (TW) | 2015-07-07 | — | — | US | disclosed |
| US-9073941-B2 | Compounds and methods for treating tuberculosis infection | ACADEMIA SINICA (TW) | 2015-07-07 | — | — | US | disclosed |
| US-20130158037-A1 | COMPOUNDS AND METHODS FOR TREATING TUBERCULOSIS INFECTION | ACADEMIA SINICA (TW) | 2013-06-20 | — | — | US | disclosed |
| US-20130158037-A1 | COMPOUNDS AND METHODS FOR TREATING TUBERCULOSIS INFECTION | ACADEMIA SINICA (TW) | 2013-06-20 | — | — | US | disclosed |
| WO-2012006104-A2 | COMPOUNDS AND METHODS FOR TREATING TUBERCULOSIS INFECTION | Academia Sinica, Taiwan (TW) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210113570-A1 | INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION | PIK3CA, PIK3CB, SAMHD1 | HSF1 3737/4885KDM4E 1235/4885MEN1 4445/4885 |
| US-20130158037-A1 | COMPOUNDS AND METHODS FOR TREATING TUBERCULOSIS INFECTION | TALDO1, PGD, DLD | HSF1 3254/4885KDM4E 903/4885MEN1 3731/4885 |
| US-10888564-B2 | Inhibitors of HIV-1 integrase multimerization | CDK7, TYMP, CDC7 | HSF1 3876/4885KDM4E 1705/4885MEN1 4371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.