Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 7/20 | 0.35 |
| ▸ | GCK | P35557 | 8/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657050 | 0.78 | GCK (0.47) | HCAR3GCKRARARARBRARG | |
| SCHEMBL2656351 | 0.70 | DEGS1 (0.42) | HCAR3GCKRARARARBRARG | |
| SCHEMBL2655247 | 0.67 | GCK (0.65) | GCK | |
| SCHEMBL2655541 | 0.66 | GCK (0.52) | HCAR3GCKRARARARBRARG | |
| SCHEMBL21062101 | 0.64 | HCAR3 (0.58) | HCAR3 | |
| SCHEMBL2655501 | 0.64 | GCK (0.62) | HCAR3GCKRARARARBRARG | |
| SCHEMBL10932719 | 0.62 | HCAR3 (0.58) | HCAR3 | |
| SCHEMBL8554805 | 0.62 | HCAR3 (0.59) | HCAR3 | |
| SCHEMBL10198818 | 0.61 | FFAR2 (0.38) | GCK | |
| SCHEMBL2656829 | 0.61 | ALDH1A1 (0.58) | HCAR3GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | disclosed |