Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 17/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.49 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21062101 | 0.87 | HCAR3 (0.58) | HCAR3HCAR2 | |
| SCHEMBL7094503 | 0.85 | DEGS1 (0.46) | HCAR3DEGS1L3MBTL1 | |
| SCHEMBL15065060 | 0.84 | HCAR3 (0.54) | HCAR3HCAR2P4HA1P4HTM | |
| SCHEMBL10932719 | 0.81 | HCAR3 (0.58) | HCAR3HCAR2P4HA1P4HTM | |
| SCHEMBL12903841 | 0.78 | KDM4E (0.41) | DEGS1L3MBTL1 | |
| SCHEMBL13656094 | 0.78 | RAB9A (0.66) | L3MBTL1 | |
| SCHEMBL6543272 | 0.78 | ALDH1A1 (0.55) | L3MBTL1 | |
| SCHEMBL2228695 | 0.78 | PTGS1 (0.61) | DEGS1L3MBTL1 | |
| SCHEMBL82675 | 0.77 | HCAR3 (0.68) | HCAR3HCAR2 | |
| SCHEMBL30753154 | 0.77 | HCAR3 (0.65) | HCAR3HCAR2P4HA1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084329-C | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2002-05-08 | — | — | CN | disclosed |
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| CN-1183768-A | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 1998-06-03 | — | — | CN | disclosed |
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |