Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.51 |
| ▸ | NPM1 | P06748 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | RHOA | P61586 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213413 | 0.82 | PDGFRB (0.74) | PDGFRBPDGFRARAB9ANPC1RHOA | |
| SCHEMBL8610333 | 0.81 | PDGFRB (1.00) | PDGFRBPDGFRARAB9ANPC1ALK | |
| SCHEMBL1401437 | 0.81 | PDGFRB (0.68) | PDGFRBPDGFRARAB9ANPC1RHOA | |
| SCHEMBL7696743 | 0.81 | PDGFRB (0.59) | PDGFRBPDGFRARAB9ANPC1ALK | |
| SCHEMBL7696400 | 0.80 | PDGFRB (0.76) | PDGFRBPDGFRARAB9ANPC1RHOA | |
| SCHEMBL7691917 | 0.79 | PDGFRB (0.56) | PDGFRBPDGFRARHOAMEN1KMT2A | |
| SCHEMBL780200 | 0.78 | PABPC1 (0.42) | PDGFRBPDGFRAMEN1KMT2AKDM4E | |
| SCHEMBL1401415 | 0.78 | PDGFRB (1.00) | PDGFRBPDGFRARAB9ANPC1MEN1 | |
| SCHEMBL18171881 | 0.78 | PDGFRB (0.61) | PDGFRBPDGFRANPC1MEN1KMT2A | |
| SCHEMBL1599044 | 0.77 | PABPC1 (0.44) | PDGFRBPDGFRAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | DGAT2, DGAT1, LCAT | PDGFRB 3777/4885PDGFRA 3456/4885RAB9A 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.