Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.31 |
| ▸ | CBFB | Q13951 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792102 | 0.74 | MAPT (0.50) | HTTALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL15256271 | 0.71 | MAPT (0.40) | HTTALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL189131 | 0.70 | MAPT (0.55) | HTTALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL14050665 | 0.70 | MAPT (0.45) | ALDH1A1MAPTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL12292981 | 0.69 | MAPT (0.39) | HTTALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL24287526 | 0.68 | MAPT (0.39) | HTTALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27518692 | 0.67 | ALDH1A1 (0.50) | HTTALDH1A1PKMHPGDL3MBTL1 | |
| SCHEMBL2192393 | 0.63 | HTT (0.39) | HTTALDH1A1PKMHPGDL3MBTL1 | |
| SCHEMBL2197156 | 0.62 | L3MBTL1 (0.51) | HTTALDH1A1PKMHPGDL3MBTL1 | |
| SCHEMBL12292714 | 0.62 | PIK3CA (0.48) | HTTMAPTKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006552-A1 | COMBINATIONS OF KINASE INHIBITORS FOR THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |