Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.45 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15256271 | 0.87 | MAPT (0.40) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL23555179 | 0.78 | MAPT (0.39) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL14306590 | 0.77 | MMP2 (0.44) | KDM4E | |
| SCHEMBL1792162 | 0.74 | MAPT (0.64) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL12292981 | 0.73 | MAPT (0.39) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL24069000 | 0.72 | MAPT (0.54) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL10198785 | 0.70 | HTT (0.36) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL12292197 | 0.70 | RHOA (0.56) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL23876430 | 0.69 | LMNA (0.58) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL24287510 | 0.68 | ALDH1A1 (0.39) | KDM4EALDH1A1LMNAHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |