Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27914203 | 1.00 | EPHX1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 | |
| SCHEMBL584831 | 1.00 | EPHX1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 | |
| SCHEMBL5495940 | 1.00 | EPHX1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 | |
| SCHEMBL2125537 | 1.00 | EPHX1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 | |
| SCHEMBL3380308 | 0.90 | EPHX1 (0.53) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 | |
| SCHEMBL24026949 | 0.90 | EPHX1 (0.49) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 | |
| SCHEMBL18629605 | 0.90 | EPHX1 (0.49) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 | |
| Nornitrogen Mustard SCHEMBL3380310 | 0.87 | EPHX1 (0.51) | EPHX1ALDH1A1HPGDCYP19A1TRPM8 | |
| SCHEMBL13468949 | 0.87 | ALDH1A1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 | |
| SCHEMBL28062170 | 0.87 | ALDH1A1 (0.58) | EPHX1ALDH1A1HPGDCYP19A1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431369-A2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC Therapeutics, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |