Sugi Predict

Sugi Predict / Compounds / SCHEMBL10199485

SCHEMBL10199485

SCHEMBL10199485

CC(=O)CNC(=O)C(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.43
▸ TDP1 Q9NUW8 3/20 0.43
▸ LMNA P02545 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ PTGS2 P35354 1/20 0.43
▸ DPP4 P27487 1/20 0.39
▸ PREP P48147 1/20 0.39
▸ FAP Q12884 1/20 0.39
▸ ECE1 P42892 1/20 0.38
▸ CYP2C19 P33261 3/20 0.37
▸ CYP2D6 P10635 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ ERCC1 P07992 1/20 0.37
▸ ERCC4 Q92889 1/20 0.37
▸ MME P08473 1/20 0.36
▸ ACE P12821 1/20 0.36
▸ CPA1 P15085 1/20 0.36
▸ ACE2 Q9BYF1 1/20 0.36
▸ TSHR P16473 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25129533 0.91 ALDH1A1 (0.38) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL12884400 0.85 ALDH1A1 (0.40) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL25514706 0.81 ALDH1A1 (0.44) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL18589992 0.80 MAPT (0.68) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL19853267 0.80 ALDH1A1 (0.40) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL7216866 0.80 TERT (0.42) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL2608304 0.80 ALDH1A1 (0.40) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL25794017 0.80 TSHR (0.40) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL12017871 0.79 ALDH1A1 (0.43) ALDH1A1TDP1LMNAMAPTPTGS2
SCHEMBL21644459 0.79 ALDH1A1 (0.43) ALDH1A1TDP1LMNAMAPTPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118007267-A Wear-resistant tough trilobal polylactic acid fiber and preparation method thereof 江苏中石纤维股份有限公司 2024-05-10 — — CN claimed
CN-118007423-A Aerogel composite acetate fiber fabric and preparation method thereof 上海沐易化工有限公司 2024-05-10 — — CN claimed
CN-113801081-B 2, 5-furandicarboxylic acid and preparation method thereof 新乡学院 2023-04-11 — — CN claimed
CN-113861142-B 2, 5-furandicarboxylic acid and preparation method thereof 新乡学院 2023-04-07 — — CN claimed
CN-113956222-A 2, 5-furandicarboxylic acid and preparation method thereof 新乡学院 2022-01-21 — — CN claimed
CN-113861142-A 2, 5-furandicarboxylic acid and preparation method thereof 新乡学院 2021-12-31 — — CN claimed
CN-113801081-A 2, 5-furandicarboxylic acid and preparation method thereof 新乡学院 2021-12-17 — — CN claimed
CN-111662158-A Preparation method of axial chiral biaryl compound and chiral fluorenol compound 武汉大学 2020-09-15 — — CN claimed
CN-118007423-A Aerogel composite acetate fiber fabric and preparation method thereof 上海沐易化工有限公司 2024-05-10 — — CN disclosed
CN-118007267-A Wear-resistant tough trilobal polylactic acid fiber and preparation method thereof 江苏中石纤维股份有限公司 2024-05-10 — — CN disclosed
CN-110090605-B Preparation equipment of functional nanometer microballoons 黄琛 2024-05-10 — — CN disclosed
WO-2024086664-A2 COVALENT INHIBITORS OF WILD-TYPE AND MUTANT PI3K AND METHOD OF USES THEREOF TOTUS MEDICINES INC. (US) 2024-04-25 — — WO disclosed
CN-114016285-B Preparation method of functional nanofiber membrane for sea water desalination 盐城工业职业技术学院 2024-01-30 — — CN disclosed
WO-2023183936-A2 COMBINATION THERAPY OF A PI3K INHIBITOR AND KRAS INHIBITOR AND METHODS OF USE THEREOF TOTUS MEDICINES INC. (US) 2023-09-28 — — WO disclosed
US-20100137306-A1 HETEROCYCLIC TRPV1 RECEPTOR LIGANDS PURDUE PHARMA L.P. 2010-06-03 — — US disclosed
US-7652041-B2 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors MILLENNIUM PHARMACEUTICALS, INC. (US) 2010-01-26 — — US disclosed
US-20080064729-A1 Phenethylamide derivatives with kinase inhibitory activity MILLENNIUM PHARMACEUTICALS, INC. (US) 2008-03-13 — — US disclosed
US-20070191604-A1 Novel compounds that are ERK inhibitors SCHERING CORPORATION 2007-08-16 — — US disclosed
US-20070149533-A1 Bicyclic compounds with kinase inhibitory activity MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-06-28 — — US disclosed
US-20070087447-A1 System and method of free radical initiated protein sequencing CALIFORNIA INSTITUTE OF TECHNOLOGY 2007-04-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070191604-A1 Novel compounds that are ERK inhibitors MAPK1, MAPK4, MAPKAPK2 ALDH1A1 342/4885TDP1 2679/4885LMNA 4536/4885
US-20080064729-A1 Phenethylamide derivatives with kinase inhibitory activity MAP4K5, MAP3K5, MAP4K2 ALDH1A1 3788/4885TDP1 1537/4885LMNA 2315/4885
US-20100137306-A1 HETEROCYCLIC TRPV1 RECEPTOR LIGANDS TRPV1, TRPA1, TRPV2 ALDH1A1 566/4885TDP1 4612/4885LMNA 3756/4885
US-20070149533-A1 Bicyclic compounds with kinase inhibitory activity MAP3K20, MAP3K1, MAP3K5 ALDH1A1 4226/4885TDP1 1298/4885LMNA 2237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.