Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.33 |
| ▸ | MTOR | P42345 | 6/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | GCKR | Q14397 | 4/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611573 | 0.81 | OPRM1 (0.45) | CHRNB2CHRNA4PIK3CAMTOROPRM1 | |
| SCHEMBL10201516 | 0.78 | MAPT (0.50) | CHRNB2CHRNA4 | |
| SCHEMBL23089116 | 0.75 | CHRNB2 (0.44) | CHRNB2CHRNA4PIK3CAMTORALOX5AP | |
| SCHEMBL23089117 | 0.75 | CHRNB2 (0.44) | CHRNB2CHRNA4PIK3CAMTORALOX5AP | |
| SCHEMBL23089115 | 0.75 | CHRNB2 (0.44) | CHRNB2CHRNA4PIK3CAMTORALOX5AP | |
| SCHEMBL20037601 | 0.73 | CHRNB2 (0.49) | CHRNB2CHRNA4PIK3CAMTOROPRM1 | |
| SCHEMBL17796315 | 0.73 | MTOR (0.46) | CHRNB2CHRNA4PIK3CAMTOR | |
| SCHEMBL609627 | 0.72 | GPR119 (0.48) | PIK3CAMTORALOX5AP | |
| SCHEMBL30512307 | 0.72 | GPR119 (0.48) | PIK3CAMTORALOX5AP | |
| SCHEMBL31073126 | 0.70 | CHRNB2 (0.39) | CHRNB2CHRNA4PIK3CAMTOROPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940741-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMANN-LA ROCHE INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-20130178461-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
| US-8481540-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMANN-LA ROCHE INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BERTHEL STEVEN JOSEPH (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | CHRNB2 4010/4885CHRNA4 3568/4885PIK3CA 177/4885 |
| US-20130178461-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | CHRNB2 4010/4885CHRNA4 3568/4885PIK3CA 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.