SCHEMBL102108

SCHEMBL102108

CCN1CCC(CCC(C)C)CC1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.38
HSD11B1 P28845 1/20 0.38
LMNA P02545 1/20 0.34
EPHX1 P07099 2/20 0.34
GNAO1 P09471 1/20 0.34
MAOB P27338 2/20 0.33
EPHX2 P34913 1/20 0.33
HTR4 Q13639 1/20 0.32
MAOA P21397 1/20 0.32
PIK3CD O00329 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24428797 0.90 HRH3 (0.34) HRH3SMN1; SMN2HSD11B1LMNAEPHX1
SCHEMBL23560328 0.88 HRH3 (0.40) HRH3SMN1; SMN2HSD11B1EPHX1GNAO1
SCHEMBL22526530 0.86 HRH3 (0.39) HRH3SMN1; SMN2HSD11B1LMNAEPHX1
SCHEMBL13967023 0.84 GNAO1 (0.42) HRH3SMN1; SMN2LMNAEPHX1GNAO1
SCHEMBL23695997 0.83 PIK3CD (0.44) HRH3SMN1; SMN2LMNAMAOBPIK3CD
SCHEMBL23105099 0.83 ARG1 (0.40) LMNAGNAO1
SCHEMBL31273888 0.82 HRH3 (0.49) HRH3SMN1; SMN2HSD11B1EPHX1GNAO1
SCHEMBL23568576 0.82 ACHE (0.42)
SCHEMBL24508739 0.81 GNAO1 (0.51) HRH3GNAO1HTR4
SCHEMBL25728347 0.81 GRIN2D (0.34) HRH3LMNAGNAO1PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024148060-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2024-07-11 WO disclosed
US-12024484-B2 Lipid formulations for gene editing VERVE THERAPEUTICS, INC. (US) 2024-07-02 US disclosed
WO-2023161876-A1 CYTOTOXICITY TARGETING CHIMERAS FOR CXCR3-EXPRESSING CELLS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-08-31 WO disclosed
US-20230234953-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-07-27 US disclosed
US-11707457-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-07-25 US disclosed
US-20230158174-A1 CHEMICALLY MODIFIED GUIDE RNAS FOR GENOME EDITING WITH CAS9 VERVE THERAPEUTICS, INC. 2023-05-25 US disclosed
US-20230159926-A1 BASE EDITING OF PCSK9 AND METHODS OF USING SAME FOR TREATMENT OF DISEASE VERVE THERAPEUTICS, INC. 2023-05-25 US disclosed
US-20230159926-A1 BASE EDITING OF PCSK9 AND METHODS OF USING SAME FOR TREATMENT OF DISEASE VERVE THERAPEUTICS, INC. 2023-05-25 US disclosed
US-20230158174-A1 CHEMICALLY MODIFIED GUIDE RNAS FOR GENOME EDITING WITH CAS9 VERVE THERAPEUTICS, INC. 2023-05-25 US disclosed
US-20230146870-A1 METHOD TO QUANTIFY AFFINITY AND SELECTIVITY OF SMALL MOLECULES FOR PROTEINS IN LIVING CELLS OHIO STATE INNOVATION FOUNDATION 2023-05-11 US disclosed
US-20140329807-A1 HETEROCYCLIC PROTEIN KINASE INHIBITORS TOLERO PHARMACEUTICALS, INC. (US) 2014-11-06 US disclosed
US-8710057-B2 Imidazo[1,2-B]pyridazine and pyrazolo[1 .5-A]pyrimidine derivatives and their use as protein kinase inhibitors TOLERO PHARMACEUTICALS, INC. (US) 2014-04-29 US disclosed
US-20120058997-A1 IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS SUPERGEN, INC. (US) 2012-03-08 US disclosed
US-20110281863-A1 IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS SUPERGEN, INC. (US) 2011-11-17 US disclosed
US-20100227861-A1 IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS SUPERGEN, INC. (US) 2010-09-09 US disclosed
US-20100227861-A1 IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS SUPERGEN, INC. (US) 2010-09-09 US disclosed
US-7750007-B2 Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors SUPERGEN, INC. (US) 2010-07-06 US disclosed
US-7750007-B2 Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors SUPERGEN, INC. (US) 2010-07-06 US disclosed
US-20080261988-A1 IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS SUPERGEN, INC. (US) 2008-10-23 US disclosed
US-20080261988-A1 IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS SUPERGEN, INC. (US) 2008-10-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12024484-B2 Lipid formulations for gene editing LIPA, LIPC, ABHD16A HRH3 4530/4885SMN1; SMN2 2103/4885HSD11B1 3806/4885
US-20230234953-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 HRH3 3631/4885SMN1; SMN2 2647/4885HSD11B1 2834/4885
US-20120058997-A1 IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS PIM1, PIM2, PIM3 HRH3 2497/4885SMN1; SMN2 3269/4885HSD11B1 3872/4885
US-20110281863-A1 IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS PIM1, PIM2, PIM3 HRH3 2497/4885SMN1; SMN2 3269/4885HSD11B1 3872/4885
US-20080261988-A1 IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS PIM1, PIM2, PIM3 HRH3 2344/4885SMN1; SMN2 3147/4885HSD11B1 3732/4885
US-20140329807-A1 HETEROCYCLIC PROTEIN KINASE INHIBITORS PIM1, PIM2, PIM3 HRH3 1740/4885SMN1; SMN2 3932/4885HSD11B1 3806/4885
US-20230159926-A1 BASE EDITING OF PCSK9 AND METHODS OF USING SAME FOR TREATMENT OF DISEASE PCSK9, LDLR, PCSK7 HRH3 4255/4885SMN1; SMN2 1454/4885HSD11B1 626/4885
US-20100227861-A1 IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS PIM1, PIM2, PIM3 HRH3 2344/4885SMN1; SMN2 3147/4885HSD11B1 3732/4885
US-20230158174-A1 CHEMICALLY MODIFIED GUIDE RNAS FOR GENOME EDITING WITH CAS9 LDLR, LIPC, SREBF2 HRH3 4212/4885SMN1; SMN2 3160/4885HSD11B1 920/4885
US-11707457-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 HRH3 3631/4885SMN1; SMN2 2647/4885HSD11B1 2834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.