Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 16/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10210052 | 0.90 | MMP13 (0.43) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL8255826 | 0.88 | MAPK1 (0.39) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL13594054 | 0.88 | MMP13 (0.47) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL8246532 | 0.88 | MMP13 (0.45) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL10210402 | 0.88 | MAPK1 (0.39) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL10209194 | 0.87 | HPGD (0.42) | MMP13ADAMTS4MMP3MAPK1 | |
| SCHEMBL10208162 | 0.87 | ADAMTS4 (0.39) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL13185514 | 0.87 | MMP13 (0.44) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL8253618 | 0.84 | MMP13 (0.47) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL10162167 | 0.84 | MMP13 (0.45) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | MMP13 1/4885ADAMTS4 38/4885MMP3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.