Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.89 |
| ▸ | SLCO1B3 | Q9NPD5 | 3/20 | 0.89 |
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.89 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.89 |
| ▸ | AR | P10275 | 1/20 | 0.89 |
| ▸ | MLNR | O43193 | 2/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.82 |
| ▸ | ALB | P02768 | 1/20 | 0.82 |
| ▸ | CNR1 | P21554 | 1/20 | 0.82 |
| ▸ | HTR2A | P28223 | 1/20 | 0.82 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.82 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.82 |
| ▸ | PGR | P06401 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | DRD1 | P21728 | 1/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12794637 | 0.96 | CYP3A4 (0.81) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| SCHEMBL10218499 | 0.95 | CYP3A4 (0.86) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| SCHEMBL12759046 | 0.94 | CYP3A4 (0.91) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| SCHEMBL10218507 | 0.94 | CYP3A4 (0.81) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| Clarithromycin SCHEMBL23309064 | 0.94 | CYP3A4 (1.00) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| Clarithromycin SCHEMBL17705916 | 0.94 | CYP3A4 (1.00) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| Clarithromycin SCHEMBL24064961 | 0.94 | CYP3A4 (1.00) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| Clarithromycin SCHEMBL12296733 | 0.94 | CYP3A4 (1.00) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| Clarithromycin SCHEMBL23854898 | 0.94 | CYP3A4 (1.00) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 | |
| Clarithromycin SCHEMBL38125 | 0.94 | CYP3A4 (1.00) | CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124744-B2 | Macrolide derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20090076253-A1 | MACROLIDE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076253-A1 | MACROLIDE DERIVATIVES | MMP9, MMP2, MMP11 | CYP3A4 1429/4885KCNH2 2490/4885SLCO1B3 3139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.