SCHEMBL1022937

SCHEMBL1022937

C#Cc1ccc2[nH]ccc2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.66
IMPDH1 P20839 1/20 0.66
GFER P55789 1/20 0.51
AHR P35869 4/20 0.50
NR4A2 P43354 2/20 0.50
CYP2A6 P11509 2/20 0.50
F7 P08709 1/20 0.50
LTA4H P09960 1/20 0.50
F3 P13726 1/20 0.50
USP2 O75604 1/20 0.50
GAA P10253 1/20 0.50
ALOX15 P16050 1/20 0.50
RAD51 Q06609 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
NPC1 O15118 1/20 0.46
APP P05067 1/20 0.43
F2 P00734 1/20 0.43
GPR84 Q9NQS5 1/20 0.42
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7091314 0.85 NPC1 (0.62) IMPDH2IMPDH1GFERAHRNR4A2
SCHEMBL4656311 0.83 AHR (0.50) IMPDH2IMPDH1AHRCYP2A6GPR84
SCHEMBL97207 0.79 IMPDH2 (0.66) IMPDH2IMPDH1GFERAHRNR4A2
SCHEMBL6445127 0.79 IMPDH2 (0.66) IMPDH2IMPDH1GFERAHRNR4A2
SCHEMBL91366 0.79 IMPDH2 (1.00) IMPDH2IMPDH1GFERAHRNR4A2
SCHEMBL30389000 0.79 IMPDH2 (1.00) IMPDH2IMPDH1GFERAHRNR4A2
Hydrochloric Acid SCHEMBL27803164 0.78 IMPDH2 (0.96) IMPDH2IMPDH1GFERAHRNR4A2
SCHEMBL28194905 0.78 IMPDH2 (0.96) IMPDH2IMPDH1GFERAHRNR4A2
SCHEMBL30906894 0.76 GFER (0.56) IMPDH2IMPDH1GFERAHRNR4A2
SCHEMBL30906895 0.76 GFER (0.56) IMPDH2IMPDH1GFERAHRNR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120136781-A ROR 1-targeted inhibitor and synthesis method and application thereof 北京大学 2025-06-13 CN claimed
WO-2024253016-A1 CHLORIDE ION SENSOR, AND DEVICE FOR DETECTING CANCER CELLS AND/OR EVALUATING DEGREE OF MALIGNANCY OF CANCER CELLS BY USING SAME 国立研究開発法人産業技術総合研究所 2024-12-12 WO claimed
CN-118085268-A Preparation method of amphiphilic molecule with aggregation-induced fluorescence color-changing characteristic 西北工业大学 2024-05-28 CN claimed
CN-120136781-A ROR 1-targeted inhibitor and synthesis method and application thereof 北京大学 2025-06-13 CN disclosed
US-12319946-B2 Methods for producing modified bacteria for production of nitroaromatics UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2025-06-03 US disclosed
EP-4549431-A1 COMPOUND FUNCTIONING AS SMARCA2/4 INHIBITOR AND USE THEREOF Gan & Lee Pharmaceuticals Co., Ltd. (CN) 2025-05-07 EP disclosed
CN-119490487-A Polysubstituted tetrahydrocarbazole compound, preparation method, pharmaceutical composition and application thereof 中国科学院上海药物研究所 2025-02-21 CN disclosed
CN-119384414-A Compound used as SMARCA2/4 inhibitor and application thereof 甘李药业股份有限公司 2025-01-28 CN disclosed
WO-2024253016-A1 CHLORIDE ION SENSOR, AND DEVICE FOR DETECTING CANCER CELLS AND/OR EVALUATING DEGREE OF MALIGNANCY OF CANCER CELLS BY USING SAME 国立研究開発法人産業技術総合研究所 2024-12-12 WO disclosed
US-20240229090-A1 MODIFIED BACTERIA FOR PRODUCTION OF NITROAROMATICS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-07-11 US disclosed
US-20240229090-A1 MODIFIED BACTERIA FOR PRODUCTION OF NITROAROMATICS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-07-11 US disclosed
US-20100305066-A1 Fused Thiophene Derivatives as Kinase Inhibitors UCB PHARMA S.A. (BE) 2010-12-02 US disclosed
CN-1751025-B Diamine derivatives DAIICHI SEIYAKU CO 2010-05-12 CN disclosed
US-7662812-B2 Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors NEUROSEARCH A/S (DK) 2010-02-16 US disclosed
WO-2009111337-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2009-09-11 WO disclosed
US-20090099153-A1 NOVEL 8,10-DIAZA-BICYCLO[4.3.1]DECANE DERIVATIVES AND THEIR MEDICAL USE ANIONA APS (DK) 2009-04-16 US disclosed
CN-101263110-A Optically active diamine derivative and process for producing the same DAIICHI SANKYO CO LTD (JP) 2008-09-10 CN disclosed
US-20080146582-A1 disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances NEUROSEARCH A/S (DK) 2008-06-19 US disclosed
EP-1863819-A2 DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHINOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS NEUROSEARCH A/S (DK) 2007-12-12 EP disclosed
WO-2006087306-A2 DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS NEUROSEARCH A/S (DK) 2006-08-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080146582-A1 disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances CHRNA6, CHRNA10, CHRNA2 IMPDH2 3490/4885IMPDH1 3294/4885GFER 1880/4885
US-20100305066-A1 Fused Thiophene Derivatives as Kinase Inhibitors PIKFYVE, PI4KA, PIK3CA IMPDH2 1378/4885IMPDH1 1332/4885GFER 4317/4885
US-20090099153-A1 NOVEL 8,10-DIAZA-BICYCLO[4.3.1]DECANE DERIVATIVES AND THEIR MEDICAL USE CHRNA10, CHRNA7, CHRNA3 IMPDH2 4208/4885IMPDH1 4092/4885GFER 2946/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.