Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 7/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023285 | 0.91 | ALK (0.40) | ALDH1A1METALKMAPTBCL6 | |
| SCHEMBL1026721 | 0.87 | JAK3 (0.42) | BCL6 | |
| SCHEMBL1027670 | 0.85 | BCL6 (0.38) | ALDH1A1METALKMAPTBCL6 | |
| SCHEMBL1026395 | 0.85 | BCL6 (0.40) | METBCL6BTK | |
| SCHEMBL1023949 | 0.84 | ALDH1A1 (0.40) | GAAALDH1A1BCL6BTK | |
| SCHEMBL1027584 | 0.84 | MAPT (0.51) | GAAALDH1A1ALOX15METALK | |
| SCHEMBL1025116 | 0.84 | MET (0.41) | ALDH1A1METALKBCL6BTK | |
| SCHEMBL1028227 | 0.83 | MEN1 (0.42) | ALKMAPTRAB9ABTK | |
| SCHEMBL1025086 | 0.83 | BCL6 (0.38) | ALDH1A1METALKMAPTBCL6 | |
| SCHEMBL13623203 | 0.82 | MET (0.48) | GAAMETALKMAPTCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |