Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3566046 | 0.94 | CHRNB2 (0.36) | CHRNB2CHRNA4KMT2ACHRNA7HTR3A | |
| SCHEMBL3549325 | 0.91 | CHRNB2 (0.35) | CHRNB2CHRNA4KMT2ACHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL1026727 | 0.88 | KDM4E (0.36) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL6625772 | 0.85 | HRH3 (0.37) | CHRNB2CHRNA4KMT2ACHRNA7HTR3A | |
| Fumaric Acid SCHEMBL1024084 | 0.81 | LMNA (0.36) | KMT2A | |
| SCHEMBL3389755 | 0.75 | GRIN2D (0.44) | KMT2AHTR3A | |
| SCHEMBL3393966 | 0.75 | ACACB (0.44) | — | |
| SCHEMBL928191 | 0.75 | CHRNA7 (0.68) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL21162698 | 0.75 | KMT2A (0.41) | CHRNB2CHRNA4KMT2ACHRNA7HTR3A | |
| SCHEMBL1450231 | 0.74 | OGA (0.37) | CHRNB2CHRNA4KMT2ACHRNA7HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863819-B1 | DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHINOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH AS (DK) | 2011-01-12 | — | — | EP | disclosed |
| EP-1805183-B1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH AS (DK) | 2010-12-29 | — | — | EP | disclosed |
| US-7662812-B2 | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors | NEUROSEARCH A/S (DK) | 2010-02-16 | — | — | US | disclosed |
| US-20080153806-A1 | Novel Diazabicyclic Aryl Derivatives And Their Medical Use | NEUROSEARCH A/S (DK) | 2008-06-26 | — | — | US | disclosed |
| US-20080146582-A1 | disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances | NEUROSEARCH A/S (DK) | 2008-06-19 | — | — | US | disclosed |
| EP-1863819-A2 | DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHINOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2007-12-12 | — | — | EP | disclosed |
| EP-1805183-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006087306-A2 | DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2006-08-24 | — | — | WO | disclosed |
| WO-2006045716-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146582-A1 | disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances | CHRNA6, CHRNA10, CHRNA2 | CHRNB2 6/4885CHRNA4 9/4885KMT2A 1865/4885 |
| US-20080153806-A1 | Novel Diazabicyclic Aryl Derivatives And Their Medical Use | CHRNA6, CHRNA10, CHRNA2 | CHRNB2 8/4885CHRNA4 7/4885KMT2A 2086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.