Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1024084 | 0.93 | LMNA (0.36) | KDM4EALDH1A1LMNAHTT | |
| SCHEMBL1023396 | 0.88 | CHRNB2 (0.37) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL3566046 | 0.82 | CHRNB2 (0.36) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL3549325 | 0.80 | CHRNB2 (0.35) | LMNAHTTCHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL27491917 | 0.78 | LMNA (0.53) | LMNAHTTCHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL1023412 | 0.78 | GRM5 (0.49) | KDM4EALDH1A1 | |
| SCHEMBL1397534 | 0.75 | HRH3 (0.37) | LMNAHTTCHRNA7HTR3ACHRNB4 | |
| SCHEMBL6625772 | 0.75 | HRH3 (0.37) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL1021509 | 0.71 | GRM5 (0.39) | KDM4EALDH1A1LMNAHTT | |
| Fumaric Acid SCHEMBL1023087 | 0.71 | NPC1 (0.43) | KDM4EALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863819-B1 | DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHINOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH AS (DK) | 2011-01-12 | — | — | EP | disclosed |