Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14204990 | 0.86 | SETDB1 (0.59) | KMT2AALDH1A1RAB9ANPC1SETDB1 | |
| SCHEMBL31426228 | 0.85 | RIPK1 (0.58) | RIPK1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL2456852 | 0.82 | KMT2A (0.58) | RIPK1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL533866 | 0.81 | MTNR1A (0.61) | KMT2ALMNAMTNR1APKMMEN1 | |
| SCHEMBL2905338 | 0.81 | RIPK1 (0.62) | RIPK1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL29639573 | 0.81 | RIPK1 (0.58) | RIPK1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL29686650 | 0.81 | MTNR1A (0.61) | KMT2ALMNAMTNR1APKMMEN1 | |
| SCHEMBL30259906 | 0.81 | RIPK1 (0.62) | RIPK1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL2904265 | 0.81 | ANPEP (0.61) | RIPK1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL5797350 | 0.81 | KMT2A (0.57) | RIPK1KMT2AALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266834-B2 | 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-02-23 | — | — | US | disclosed |
| EP-2426125-B1 | 1,4 disubstituted 3 cyano pyridone derivatives and their use as positive allosteric modulators of mGluR2 receptors | JANSSEN PHARMACEUTICALS INC (US) | 2015-12-02 | — | — | EP | disclosed |
| US-20140315903-A1 | 1, 4-Disubstituted 3-Cyano-Pyridone Derivatives and Their Use As Positive Allosteric Modulators of MGLUR2-Receptors | JANSSEN PHARMACEUTICALS INC (US) | 2014-10-23 | — | — | US | disclosed |
| US-8841323-B2 | 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors | Janssen Pharmaceuticals, Inc. (US) | 2014-09-23 | — | — | US | disclosed |
| EP-2190811-B1 | RENIN INHIBITORS | MERCK CANADA INC (CA) | 2013-08-07 | — | — | EP | disclosed |
| EP-1994004-B9 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |
| US-8334308-B2 | Renin inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-18 | — | — | US | disclosed |
| US-8334308-B2 | Renin inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-18 | — | — | US | disclosed |
| US-8334308-B2 | Renin inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-18 | — | — | US | disclosed |
| EP-1994004-B1 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2012-08-01 | — | — | EP | disclosed |
| CN-100503551-C | Process for producing benzylamine derivative | IHARA CHEMICAL IND CO (JP) | 2009-06-24 | — | — | CN | disclosed |
| CN-101400654-A | 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2 receptors | ORTHO MCNEIL JANSSEN PHARM (US) | 2009-04-01 | — | — | CN | disclosed |
| WO-2009023964-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009023964-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-02-26 | — | — | WO | disclosed |
| US-7326813-B2 | Process for producing benzylamine derivative | IHARA CHEMICAL INDUSTRY (JP) | 2008-02-05 | — | — | US | disclosed |
| US-20060155141-A1 | Process for producing benzylamine derivative | ITO AKINORI | 2006-07-13 | — | — | US | disclosed |
| CN-1802343-A | Process for producing benzylamine derivative | IHARA CHEMICAL IND CO (JP) | 2006-07-12 | — | — | CN | disclosed |
| EP-1586552-A1 | PROCESS FOR PRODUCING BENZYLAMINE DERIVATIVE | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2005-10-19 | — | — | EP | disclosed |
| US-5039673-A | Anticoagulants, bronchodilators, vasodilators | GLAXO GROUP LIMITED (GB) | 1991-08-13 | — | — | US | disclosed |
| EP-0296802-A1 | Aminocyclopentyl ethers and their preparation and pharmaceutical formulation | GLAXO GROUP LIMITED (GB) | 1988-12-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060155141-A1 | Process for producing benzylamine derivative | BRD7, BRD1, BRD2 | RIPK1 4019/4885KMT2A 404/4885ALDH1A1 2660/4885 |
| US-20140315903-A1 | 1, 4-Disubstituted 3-Cyano-Pyridone Derivatives and Their Use As Positive Allosteric Modulators of MGLUR2-Receptors | GRM2, GRM1, GRM3 | RIPK1 897/4885KMT2A 1837/4885ALDH1A1 2839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.