Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.44 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.44 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 2/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853178 | 0.82 | TPSAB1 (0.47) | TPSAB1TPSD1TPSG1MAPTSYK | |
| SCHEMBL4848153 | 0.81 | TPSAB1 (0.47) | TPSAB1TPSD1TPSG1MAPTSYK | |
| SCHEMBL7451829 | 0.81 | FOLH1 (0.47) | TPSAB1TPSD1TPSG1MAPTSYK | |
| SCHEMBL1021431 | 0.81 | MAPT (0.48) | MAPTKLK7KLK5CPB1CPB2 | |
| SCHEMBL4852331 | 0.77 | MAPT (0.46) | MAPTKLK7KLK5CPB1CPB2 | |
| SCHEMBL21460905 | 0.77 | MAPT (0.51) | TPSAB1TPSD1TPSG1MAPTSYK | |
| SCHEMBL21460902 | 0.77 | MAPT (0.51) | TPSAB1TPSD1TPSG1MAPTSYK | |
| SCHEMBL4857153 | 0.77 | SIRT2 (0.47) | TPSAB1MAPTSYKKLK7KLK5 | |
| SCHEMBL4847771 | 0.76 | MEN1 (0.38) | — | |
| SCHEMBL8911004 | 0.75 | SYK (0.47) | TPSAB1TPSD1TPSG1MAPTSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797110-B1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO KG (DE) | 2011-01-12 | — | — | EP | disclosed |
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | AICURIS GMBH & CO. KG (DE) | 2008-11-06 | — | — | US | disclosed |
| US-7446102-B2 | Antibacterial amide macrocycles IV | AICURIS GMBH & CO. KG (DE) | 2008-11-04 | — | — | US | disclosed |
| US-20080076745-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO. KG (DE) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076745-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | NOD2, AAAS, AADAC | TPSAB1 3589/4885TPSD1 4342/4885TPSG1 4397/4885 |
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | ARG1, HRH3, H1-0 | TPSAB1 3984/4885TPSD1 4010/4885TPSG1 4657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.