Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13189778 | 0.77 | CYP11B1 (0.40) | CYP11B1CYP11B2KCNN4KCNA3KMT2A | |
| SCHEMBL6762492 | 0.76 | DRD1 (0.31) | KMT2ACYP3A4MEN1CYP1A2CYP2D6 | |
| SCHEMBL28999271 | 0.74 | CYP11B1 (0.38) | CYP11B1CYP11B2KCNN4KCNA3KMT2A | |
| SCHEMBL15528498 | 0.73 | CYP11B1 (0.40) | CYP11B1CYP11B2KCNN4KCNA3KMT2A | |
| SCHEMBL20361855 | 0.73 | CYP11B1 (0.40) | CYP11B1CYP11B2KCNN4KCNA3KMT2A | |
| SCHEMBL20360982 | 0.73 | KCNN4 (0.44) | CYP11B1CYP11B2KCNN4KCNA3KMT2A | |
| SCHEMBL6923638 | 0.73 | POLB (0.47) | CYP11B1CYP11B2KCNN4KCNA3KMT2A | |
| SCHEMBL11523600 | 0.70 | CYP11B1 (0.38) | CYP11B1CYP11B2KCNN4KCNA3KMT2A | |
| SCHEMBL13492177 | 0.69 | POLB (0.52) | CYP3A4CYP2C19KDM4EATMALDH1A1 | |
| SCHEMBL5361990 | 0.69 | CYP11B1 (0.37) | CYP11B1CYP11B2KCNN4KCNA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193372-B2 | Phosphothiophene and phosphothiazole HCV polymerase inhibitors | IDENIX PHARMACEUTICALS, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20100233123-A1 | PHOSPHOTHIOPHENE AND PHOSPHOTHIAZOLE HCV POLYMERASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100233123-A1 | PHOSPHOTHIOPHENE AND PHOSPHOTHIAZOLE HCV POLYMERASE INHIBITORS | PPP3CB, POLR2E, PSAT1 | CYP11B1 1848/4885CYP11B2 2354/4885KCNN4 3898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.