Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 8/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1023947 | 0.88 | CTSC (0.38) | CTSCBCL6BTKEGFRMET | |
| SCHEMBL4348211 | 0.86 | BTK (0.38) | CTSCBTKEGFRJAK3 | |
| SCHEMBL1026533 | 0.80 | HSD11B1 (0.33) | — | |
| Trifluoroacetic Acid SCHEMBL4348204 | 0.80 | CTSC (0.41) | CTSCBCL6BTKEGFRJAK3 | |
| SCHEMBL13623196 | 0.78 | SYK (0.45) | CTSCBCL6BTKEGFRMET | |
| SCHEMBL1026395 | 0.77 | BCL6 (0.40) | CTSCBCL6BTKEGFRMET | |
| SCHEMBL1026721 | 0.74 | JAK3 (0.42) | CTSCBCL6PTK2JAK2JAK3 | |
| SCHEMBL1023285 | 0.73 | ALK (0.40) | BCL6BTKMET | |
| SCHEMBL1025086 | 0.72 | BCL6 (0.38) | CTSCBCL6BTKEGFRMET | |
| SCHEMBL1026953 | 0.72 | GAA (0.47) | BCL6BTKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |