Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1026532 | 0.84 | CRHBP (0.40) | HSD11B1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL1023948 | 0.80 | CTSC (0.35) | — | |
| SCHEMBL1026531 | 0.77 | ALDH1A1 (0.41) | HSD11B1HDAC6MGLLL3MBTL1 | |
| SCHEMBL1028316 | 0.70 | OPRM1 (0.43) | KMT2A | |
| SCHEMBL1026191 | 0.69 | MAOA (0.50) | HSD11B1CRHBPCRHR2KMT2AL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL1026530 | 0.69 | ALDH1A1 (0.44) | HDAC6L3MBTL1 | |
| SCHEMBL1026880 | 0.69 | THRA (0.39) | HSD11B1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL13623194 | 0.67 | AURKA (0.44) | HDAC6 | |
| SCHEMBL1026509 | 0.66 | CYP1A2 (0.36) | HSD11B1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL6956921 | 0.66 | GRIN2D (0.45) | HSD11B1HDAC6KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |