Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.56 |
| ▸ | PI4KA | P42356 | 3/20 | 0.56 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.56 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 6/20 | 0.50 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | SRC | P12931 | 5/20 | 0.50 |
| ▸ | ABL2 | P42684 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16254729 | 0.86 | METTL3 (0.53) | ADORA2AADORA3ADORA1PI4KAPI4K2B | |
| SCHEMBL16236292 | 0.86 | MEN1 (0.50) | ADORA2AADORA3ADORA1PI4KAPI4K2B | |
| SCHEMBL30544051 | 0.85 | PRMT5 (0.53) | ADORA2AADORA3ADORA1PI4KAPI4K2B | |
| SCHEMBL2740574 | 0.84 | ADK (0.48) | MEN1ADKPRMT5WDR77 | |
| SCHEMBL16237556 | 0.82 | SRC (0.48) | ADORA2AADORA3ADORA1PI4KAPI4K2B | |
| SCHEMBL17830246 | 0.82 | MEN1 (0.49) | ADORA2AADORA3ADORA1PI4KAPI4K2B | |
| SCHEMBL30544119 | 0.82 | MEN1 (0.49) | ADORA2AMEN1ADKPRMT5WDR77 | |
| SCHEMBL14447403 | 0.81 | MEN1 (0.43) | ADORA2API4KBABL1EGFRSRC | |
| SCHEMBL1939828 | 0.81 | PIP4K2A (0.44) | ADORA2AADORA3ADORA1PI4KAPI4K2B | |
| SCHEMBL17818386 | 0.80 | MEN1 (0.48) | SRCMEN1MAP4K4RETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766474-B1 | INHIBITION AND ENHANCEMENT OF REPROGRAMMING BY CHROMATIN MODIFYING ENZYMES | CHILDRENS MEDICAL CENTER (US) | 2020-10-07 | — | — | EP | disclosed |
| WO-2019060536-A1 | COCRYSTAL FORMS OF ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL) METHYL SULFAMATE, FORMULATIONS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-03-28 | — | — | WO | disclosed |
| EP-2402334-A1 | Inhibitors of E1 Activating Enzymes | Millennium Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2007092213-A2 | INHIBITORS OF E1 ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-08-16 | — | — | WO | disclosed |