Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19694652 | 0.85 | HTR2C (0.46) | ATMNPSR1RECQL | |
| SCHEMBL15743974 | 0.74 | TACR1 (0.40) | TACR1KCNH2 | |
| SCHEMBL13394555 | 0.74 | TACR1 (0.33) | TACR1ATMNPSR1KCNH2 | |
| SCHEMBL6958220 | 0.71 | P2RX7 (0.40) | — | |
| SCHEMBL20956906 | 0.70 | ABCC9 (0.43) | — | |
| SCHEMBL2385210 | 0.70 | TACR1 (0.47) | TACR1 | |
| SCHEMBL20780480 | 0.70 | TACR1 (0.37) | TACR1KCNH2 | |
| SCHEMBL13413567 | 0.70 | TACR1 (0.37) | TACR1 | |
| SCHEMBL7018969 | 0.68 | CYP19A1 (0.44) | — | |
| SCHEMBL20794021 | 0.68 | ADRB1 (0.37) | TACR1KCNH2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765793-B1 | ANACETRAPIB AND OTHER CETP INHIBITPRS | MERCK SHARP & DOHME (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |