Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16688540 | 0.86 | APEX1 (0.56) | APEX1ALDH1A1GAANPC1MEN1 | |
| SCHEMBL5329443 | 0.86 | APEX1 (0.82) | APEX1ALDH1A1GAANPC1MEN1 | |
| SCHEMBL4621924 | 0.84 | ALDH1A1 (0.59) | APEX1ALDH1A1GAANPC1MEN1 | |
| SCHEMBL13332552 | 0.79 | MAPT (0.61) | APEX1ALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL9631422 | 0.76 | ALDH1A1 (0.50) | APEX1ALDH1A1GAANPC1MEN1 | |
| SCHEMBL22700984 | 0.76 | HTT (0.69) | APEX1ALDH1A1GAANPC1MEN1 | |
| SCHEMBL5324208 | 0.76 | ALDH1A1 (0.67) | APEX1ALDH1A1GAANPC1MEN1 | |
| SCHEMBL6909959 | 0.76 | PGR (0.53) | ALDH1A1GAAKDM4EMAPTGFER | |
| SCHEMBL5328824 | 0.76 | ALDH1A1 (0.58) | APEX1ALDH1A1GAANPC1MEN1 | |
| SCHEMBL3301756 | 0.75 | TMEM97 (0.51) | APEX1ALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | APEX1 4101/4885ALDH1A1 102/4885GAA 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.