Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.65 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.65 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL4730550 | 0.90 | OPRD1 (0.72) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL12082104 | 0.89 | OPRM1 (0.80) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL14112546 | 0.86 | OPRM1 (0.67) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL28468334 | 0.86 | OPRM1 (0.62) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL6755526 | 0.85 | OPRD1 (0.79) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL28470432 | 0.85 | OPRD1 (0.63) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL29416620 | 0.84 | OPRD1 (0.78) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL547917 | 0.84 | OPRD1 (0.78) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL12195952 | 0.84 | OPRM1 (0.74) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL12195953 | 0.84 | OPRM1 (0.74) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148284-A1 | Controlled Release of Phenolic Opioids | PHARMACOFORE, INC. | 2015-05-28 | — | — | US | disclosed |
| US-8921418-B2 | Controlled release of phenolic opioids | SIGNATURE THERAPEUTICS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921418-B2 | Controlled release of phenolic opioids | SIGNATURE THERAPEUTICS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2046393-B1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | SIGNATURE THERAPEUTICS INC (US) | 2014-02-12 | — | — | EP | disclosed |
| US-20120270894-A1 | Controlled Release of Phenolic Opioids | 3I, LP | 2012-10-25 | — | — | US | disclosed |
| US-20120270894-A1 | Controlled Release of Phenolic Opioids | 3I, LP | 2012-10-25 | — | — | US | disclosed |
| US-8217005-B2 | Controlled release of phenolic opioids | SIGNATURE THERAPEUTICS, INC. (US) | 2012-07-10 | — | — | US | disclosed |
| US-8217005-B2 | Controlled release of phenolic opioids | SIGNATURE THERAPEUTICS, INC. (US) | 2012-07-10 | — | — | US | disclosed |
| EP-2402037-A1 | Controlled release of phenolic opioids | Pharmacofore, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| US-20100035826-A1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | Phamacofoce, Inc. (CA) | 2010-02-11 | — | — | US | disclosed |
| US-20100035826-A1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | Phamacofoce, Inc. (CA) | 2010-02-11 | — | — | US | disclosed |
| WO-2007140272-A2 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | PHARMACOFORE, INC. (US) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270894-A1 | Controlled Release of Phenolic Opioids | OPRK1, OPRM1, OPRD1 | OPRM1 2/4885OPRD1 3/4885OPRK1 1/4885 |
| US-20150148284-A1 | Controlled Release of Phenolic Opioids | OPRK1, OPRM1, OPRD1 | OPRM1 2/4885OPRD1 3/4885OPRK1 1/4885 |
| US-20100035826-A1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | OPRK1, OPRM1, OPRD1 | OPRM1 2/4885OPRD1 3/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.