Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.50 |
| ▸ | PRF1 | P14222 | 3/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | TARS1 | P26639 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956179 | 0.83 | CA12 (0.48) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL20599741 | 0.83 | CA12 (0.48) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL14847350 | 0.82 | GSK3B (0.54) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL15962138 | 0.82 | CLK4 (0.54) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL10243599 | 0.81 | PARP10 (0.74) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL8167297 | 0.80 | CLK4 (0.75) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL15962134 | 0.80 | CLK4 (0.54) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL14847333 | 0.80 | GSK3B (0.58) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL14847341 | 0.79 | PARP10 (0.50) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL13680532 | 0.78 | CLK4 (0.78) | CLK4GSK3BDAPK3NTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630979-B2 | Inhibitors of monoacylglycerol lipase and methods of their use | INFINITY PHARMACEUTICALS, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-20140235580-A1 | INHIBITORS OF MONOACYLGLYCEROL LIPASE AND METHODS OF THEIR USE | INFINITY PHARMACEUTICALS, INC. | 2014-08-21 | — | — | US | disclosed |
| WO-2013049332-A1 | INHIBITORS OF MONOACYLGLYCEROL LIPASE AND METHODS OF THEIR USE | INFINITY PHARMACEUTICALS, INC. (US) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235580-A1 | INHIBITORS OF MONOACYLGLYCEROL LIPASE AND METHODS OF THEIR USE | MGLL, PNLIP, LIPC | CLK4 2289/4885GSK3B 1577/4885DAPK3 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.