Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL713343 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL342492 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL27092735 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL6871005 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6052835 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL342490 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6871002 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL713345 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL9768396 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL11769949 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107338101-B | Composite lubricating oil suitable for low-temperature environment and preparation method thereof | 北京睿曼科技有限公司 | 2020-03-13 | — | — | CN | claimed |
| US-9777242-B2 | Lubricating oil composition for timepiece and timepiece | CITIZEN WATCH CO., LTD. (JP) | 2017-10-03 | — | — | US | claimed |
| EP-2949734-B1 | CLOCK LUBRICATING-OIL COMPOSITION AND CLOCK | CITIZEN WATCH CO LTD (JP) | 2017-06-28 | — | — | EP | claimed |
| EP-2949734-A1 | CLOCK LUBRICATING-OIL COMPOSITION AND CLOCK | Citizen Holdings Co., Ltd. (JP) | 2015-12-02 | — | — | EP | claimed |
| US-20150337233-A1 | LUBRICATING OIL COMPOSITION FOR TIMEPIECE AND TIMEPIECE | CITIZEN WATCH CO., LTD. (JP) | 2015-11-26 | — | — | US | claimed |
| EP-1642958-B1 | Use of a lubricating oil composition in a watch and watch containing the same | CITIZEN HOLDINGS CO LTD (JP) | 2010-07-28 | — | — | EP | claimed |
| EP-1201734-B1 | Use of a LUBRICATING OIL COMPOSITION in a watch AND WATCH CONTAINING THE SAME | CITIZEN WATCH CO LTD (JP) | 2006-06-14 | — | — | EP | claimed |
| EP-1642958-A1 | Lubricating oil composition and watch using the same | Citizen Watch Co., Ltd. (JP) | 2006-04-05 | — | — | EP | claimed |
| US-6858567-B2 | Lubricating oil composition and watch using the same | CITIZEN WATCH CO., LTD. (JP) | 2005-02-22 | — | — | US | claimed |
| US-20030050197-A1 | Lubricating oil composition and watch using the same | CITIZEN WATCH CO., LTD. (JP) | 2003-03-13 | — | — | US | claimed |
| EP-1201734-A1 | LUBRICATING OIL COMPOSITIONS AND WATCH CONTAINING THE SAME | Citizen Watch Co. Ltd. (JP) | 2002-05-02 | — | — | EP | claimed |
| CN-110494538-B | Lubricant composition for wristwatch, treatment liquid for wristwatch lubrication, and wristwatch | 西铁城时计株式会社 | 2022-10-25 | — | — | CN | disclosed |
| CN-107118826-B | Composite lubricating oil antifriction and antiwear additive, composite lubricating oil and preparation method thereof | 河北京津冀再制造产业技术研究有限公司 | 2020-10-02 | — | — | CN | disclosed |
| CN-107338101-B | Composite lubricating oil suitable for low-temperature environment and preparation method thereof | 北京睿曼科技有限公司 | 2020-03-13 | — | — | CN | disclosed |
| CN-110494538-A | The treatment fluid and wrist-watch of the lubricant compositions of wrist-watch, wrist-watch lubrication | CITIZEN WATCH CO LTD | 2019-11-22 | — | — | CN | disclosed |
| EP-1642958-A1 | Lubricating oil composition and watch using the same | Citizen Watch Co., Ltd. (JP) | 2006-04-05 | — | — | EP | disclosed |
| EP-1632555-A1 | Lubricating oil composition and watch using the same | Citizen Watch Co., Ltd. (JP) | 2006-03-08 | — | — | EP | disclosed |
| US-6858567-B2 | Lubricating oil composition and watch using the same | CITIZEN WATCH CO., LTD. (JP) | 2005-02-22 | — | — | US | disclosed |
| US-20030050197-A1 | Lubricating oil composition and watch using the same | CITIZEN WATCH CO., LTD. (JP) | 2003-03-13 | — | — | US | disclosed |
| EP-1201734-A1 | LUBRICATING OIL COMPOSITIONS AND WATCH CONTAINING THE SAME | Citizen Watch Co. Ltd. (JP) | 2002-05-02 | — | — | EP | disclosed |