Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28945593 | 1.00 | TSHR (0.60) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL6871005 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL342490 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6871002 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL342492 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL713345 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6052835 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL1024373 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL713343 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL27092735 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104882282-B | Super-pressure Large Copacity working electrolyte for aluminium electrolytic capacitor and preparation method thereof | 南通新三能电子有限公司 | 2017-10-27 | — | — | CN | claimed |
| CN-104882282-A | Ultrahigh-voltage large-capacity aluminum electrolytic capacitor work electrolyte and preparation method thereof | NANTONG SUNION ELECTRONIC CO LTD | 2015-09-02 | — | — | CN | claimed |
| JP-3173680-A | — | — | None | — | — | JP | disclosed |
| CN-115662791-A | Working electrolyte of large-capacity aluminum electrolytic capacitor and capacitor | 南通瑞达电子材料有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-115662791-A | Working electrolyte of large-capacity aluminum electrolytic capacitor and capacitor | 南通瑞达电子材料有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-104845428-B | Compositions of additives, adiabatic coating and purposes | 赵石林 | 2017-10-31 | — | — | CN | disclosed |
| CN-104882282-B | Super-pressure Large Copacity working electrolyte for aluminium electrolytic capacitor and preparation method thereof | 南通新三能电子有限公司 | 2017-10-27 | — | — | CN | disclosed |
| CN-106084962-A | Adiabatic compositions of additives and purposes | 广东佳士利纳米涂料科技有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-104882282-A | Ultrahigh-voltage large-capacity aluminum electrolytic capacitor work electrolyte and preparation method thereof | NANTONG SUNION ELECTRONIC CO LTD | 2015-09-02 | — | — | CN | disclosed |
| CN-104845428-A | Additive composition, thermal-insulation paint and application thereof | ZHAO SHILIN | 2015-08-19 | — | — | CN | disclosed |
| JP-H03173680-A | MANUFACTURE OF THERMOSENSITIVE RECORDING MATERIAL | OJI PAPER CO LTD | 1991-07-26 | — | — | JP | disclosed |