Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL713343 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL342492 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL27092735 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL6871005 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6052835 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL342490 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6871002 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL1024373 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL9768396 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL11769949 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117460497-A | Pharmaceutical composition for preventing or treating viral infections comprising polymer nanodiscs | MVRIX株式会社 | 2024-01-26 | — | — | CN | claimed |
| US-20240029963-A1 | AMPHIPHILIC CO-POLYMER LIPID PARTICLES, METHODS OF MAKING SAME, AND PHOTO-ELECTRICAL ENERGY GENERATING DEVICES INCORPORATING SAME | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2024-01-25 | — | — | US | claimed |
| CN-117136191-A | Method for purifying proteins derived from membrane protein complexes | 住友橡胶工业株式会社 | 2023-11-28 | — | — | CN | claimed |
| CN-116607324-A | Water-repellent and oil-repellent composition for nonwoven fabric and nonwoven fabric product | 大金工业株式会社 | 2023-08-18 | — | — | CN | claimed |
| CN-114729030-A | Virus-like particle vaccine | 沃达瑞公司 | 2022-07-08 | — | — | CN | claimed |
| US-20220181090-A1 | AMPHIPHILIC CO-POLYMER LIPID PARTICLES, METHODS OF MAKING SAME, AND PHOTO-ELECTRICAL ENERGY GENERATING DEVICES INCORPORATING SAME | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2022-06-09 | — | — | US | claimed |
| WO-2020219409-A1 | AMPHIPHILIC CO-POLYMER LIPID PARTICLES, METHODS OF MAKING SAME, AND PHOTO-ELECTRICAL ENERGY GENERATING DEVICES INCORPORATING SAME | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2020-10-29 | — | — | WO | claimed |
| CN-104508107-B | Solid cleaning agent composition | 花王株式会社 | 2017-09-22 | — | — | CN | claimed |
| CN-102532382-A | Preparation method of polydiisobutylene-fatty monoamide maleate-acrylic acid leather retanning-fatting agent | DONGYING LIYING CHEMICAL CO LTD | 2012-07-04 | — | — | CN | claimed |
| CN-101074455-A | Production of fast-drying water self-stripping metal heat treatment protecting coating | UNIV SHANGHAI COMMUNICATION (CN) | 2007-11-21 | — | — | CN | claimed |
| JP-2112476-A | — | — | None | — | — | JP | disclosed |
| US-20240239930-A1 | FUNCTIONALIZED MALEIC ACID COPOLYMERS FOR ENHANCED BIOACTIVITY | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2024-07-18 | — | — | US | disclosed |
| US-20240239930-A1 | FUNCTIONALIZED MALEIC ACID COPOLYMERS FOR ENHANCED BIOACTIVITY | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2024-07-18 | — | — | US | disclosed |
| US-20240174989-A1 | METHOD FOR PURIFYING PROTEIN DERIVED FROM MEMBRANE PROTEIN COMPLEX | SUMITOMO RUBBER INDUSTRIES, LTD. (JP) | 2024-05-30 | — | — | US | disclosed |
| EP-4334365-A1 | FUNCTIONALIZED MALEIC ACID COPOLYMERS FOR ENHANCED BIOACTIVITY | University of Tennessee Research Foundation (US) | 2024-03-13 | — | — | EP | disclosed |
| EP-0156494-B1 | LIQUID DEVELOPER FOR ELECTROSTATIC PHOTOGRAPHY | FUJI PHOTO FILM CO., LTD. (JP) | 1988-07-27 | — | — | EP | disclosed |
| US-4729671-A | FOR FROZEN FOODS AND DRUGS, METHANE DYES | MITSUI TOATSU CHEMICALS, INC. (JP) | 1988-03-08 | — | — | US | disclosed |
| US-4579803-A | COPOLYMERS AND TERPOLYMERS; ETHYLENICALLY UNSATURATED MONOMERS | FUJI PHOTO FILM CO., LTD. (JP) | 1986-04-01 | — | — | US | disclosed |
| EP-0156912-A1 | TEMPERATURE SUPERVISION AND DISPLAY UNIT | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1985-10-09 | — | — | EP | disclosed |
| EP-0156494-A1 | Liquid developer for electrostatic photography | FUJI PHOTO FILM CO., LTD. (JP) | 1985-10-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240174989-A1 | METHOD FOR PURIFYING PROTEIN DERIVED FROM MEMBRANE PROTEIN COMPLEX | VAMP8, VAMP7, MAX | TSHR 3484/4885TP53 4138/4885EGLN1 4823/4885 |
| US-20240239930-A1 | FUNCTIONALIZED MALEIC ACID COPOLYMERS FOR ENHANCED BIOACTIVITY | MDH2, ME1, DDAH1 | TSHR 1900/4885TP53 2291/4885EGLN1 3268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.