Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL713343 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL27092735 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL6871005 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6052835 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL342490 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL6871002 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL713345 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL1024373 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL9768396 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL11769949 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 680 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117282246-A | Denitration agent and application thereof | 北京华能长江环保科技研究院有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-114085549-A | Green pigment dispersion liquid for color filter and preparation method thereof | 西安思摩威新材料有限公司 | 2022-02-25 | — | — | CN | claimed |
| CN-113861764-A | High-water-resistance polymer cement waterproof coating and preparation process thereof | 宏源防水科技集团有限公司 | 2021-12-31 | — | — | CN | claimed |
| EP-2928625-B1 | SOIL REMEDIATION COMPOSITION | INJEKTA ENV PTY LTD (AU) | 2021-11-17 | — | — | EP | claimed |
| US-11166414-B2 | Soil remediation composition | INJEKTA ENVIRONMENTAL PTY LTD (AU) | 2021-11-09 | — | — | US | claimed |
| CN-112625777-A | Preparation method of lubricating oil antiwear dispersant | 中国石油天然气股份有限公司 | 2021-04-09 | — | — | CN | claimed |
| CN-107500498-B | Bottom mud modifier and preparation method and application thereof | 广东益诺欧环保股份有限公司 | 2020-06-09 | — | — | CN | claimed |
| CN-110432272-A | A kind of environment-friendly type trees prevention and control of plant diseases, pest control microbial pesticide | SHANDONG BIO BIOTECHNOLOGY CO LTD | 2019-11-12 | — | — | CN | claimed |
| CN-105188970-B | Soil remediation composition | 英洁克达环境有限责任公司 | 2019-07-23 | — | — | CN | claimed |
| US-10172293-B2 | Soil remediation composition | INJEKTA ENVIRONMENTAL PTY LTD (AU) | 2019-01-08 | — | — | US | claimed |
| EP-0872536-A2 | Process and system for converting plastics waste into oil | TOHOKU ELECTRIC POWER CO., INC. (JP) | 1998-10-21 | — | — | EP | claimed |
| US-5820763-A | PASSING PORTION OF WATER THROUGH ANION EXCHANGER CONTAINING BICARBONATE ANIONS, PASSING REMAINER THROUGH ANION EXCHANGER CONTAINING HYDROXIDE IONS, ADDING CHLORINE-CONTAINING SLIME CONTROLLING AGENT | KURITA WATER INDUSTRIES, LTD. (JP) | 1998-10-13 | — | — | US | claimed |
| EP-0866148-A1 | Method for inhibiting corrosion in water systems | KURITA WATER INDUSTRIES LTD. (JP) | 1998-09-23 | — | — | EP | claimed |
| US-5695779-A | Release controlled transdermal therapeutic system | LEAD CHEMICAL CO., LTD. (JP) | 1997-12-09 | — | — | US | claimed |
| EP-0761241-A2 | Absorbing agent composition, absorbent material, and absorbent product containing absorbent material | NIPPON SHOKUBAI CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |
| EP-0739626-A2 | Release controlled transdermal therapeutic system | LEAD CHEMICAL COMPANY LTD. (JP) | 1996-10-30 | — | — | EP | claimed |
| EP-0399432-B1 | Transdermal therapeutic composition | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-06-22 | — | — | EP | claimed |
| US-5176916-A | Plaster layer containing a medicinal ingredient, hydrophobic polymer, absorption promoter, water and a hydrophilic polymer | NITTO ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1993-01-05 | — | — | US | claimed |
| EP-0137538-B1 | BIOPOLYMER FORMULATIONS AND PROCESSES FOR PREPARING THEM | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-03-14 | — | — | EP | claimed |
| US-4374895-A | ELECTROCONDUCTIVE LAYER COMPRISING ZINC OXIDE DOPED WITH ALUMINUM, COPPER, OR TIN, A FLUORESCENT BRIGHTNER, AND A BINDER; IMAGES | OJI PAPER CO., LTD. (JP) | 1983-02-22 | — | — | US | claimed |