Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.61 |
| ▸ | AGXT | P21549 | 3/20 | 0.58 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.47 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.47 |
| ▸ | CHKA | P35790 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19601451 | 0.96 | PRMT6 (0.57) | PRMT6AGXTL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL8222798 | 0.86 | AGXT (0.63) | PRMT6AGXTL3MBTL3L3MBTL1DRD2 | |
| SCHEMBL166575 | 0.85 | PRMT6 (0.65) | PRMT6AGXTL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL8189516 | 0.85 | AGXT (0.61) | PRMT6AGXTL3MBTL3L3MBTL1MEN1 | |
| SCHEMBL8323984 | 0.85 | AGXT (0.47) | PRMT6AGXTL3MBTL3L3MBTL1DRD2 | |
| SCHEMBL4480384 | 0.84 | PRMT6 (0.68) | PRMT6AGXTL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL4806907 | 0.82 | AGXT (0.58) | PRMT6AGXTL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL19604155 | 0.81 | PRMT6 (0.60) | PRMT6AGXTL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL19364977 | 0.81 | SIGMAR1 (0.47) | AGXTDRD2DRD4DRD3 | |
| SCHEMBL4576036 | 0.81 | PRMT6 (0.59) | PRMT6AGXTL3MBTL3L3MBTL1MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-28 | — | — | US | disclosed |
| US-20120022043-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022043-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | PRMT6 710/4885AGXT 2826/4885L3MBTL3 2106/4885 |
| US-20120165309-A1 | HETERO RING DERIVATIVE | IL2, PIK3R2, IL2RA | PRMT6 4271/4885AGXT 3766/4885L3MBTL3 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.