Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105420 | 0.82 | TTR (0.70) | SMN1; SMN2ALDH1A1TTRCYP1A2CYP3A4 | |
| SCHEMBL875806 | 0.80 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1TTRLMNATDP1 | |
| SCHEMBL7995147 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TTRLMNATDP1 | |
| SCHEMBL2031421 | 0.78 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1LMNATDP1CYP19A1 | |
| SCHEMBL7390045 | 0.78 | CYP1A2 (0.66) | SMN1; SMN2ALDH1A1LMNATDP1CYP19A1 | |
| SCHEMBL4938372 | 0.77 | LMNA (0.68) | SMN1; SMN2ALDH1A1LMNATDP1MKNK1 | |
| SCHEMBL2646628 | 0.76 | ALDH1A1 (0.62) | SMN1; SMN2ALDH1A1LMNATDP1CYP19A1 | |
| SCHEMBL11478665 | 0.75 | LMNA (0.53) | SMN1; SMN2ALDH1A1LMNATDP1CYP19A1 | |
| SCHEMBL15779486 | 0.75 | LMNA (0.53) | SMN1; SMN2ALDH1A1LMNATDP1CYP19A1 | |
| SCHEMBL2933241 | 0.74 | L3MBTL1 (0.60) | SMN1; SMN2ALDH1A1LMNATDP1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037782-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | GLAXO GROUP LIMITED (GB) | 2012-03-29 | — | — | WO | disclosed |