Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.76 |
| ▸ | VCP | P55072 | 4/20 | 0.76 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.68 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.68 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | GAA | P10253 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | CFTR | P13569 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL205976 | 0.89 | ALOX5 (0.80) | ALOX5VCPAMY1AMAPTGAA | |
| SCHEMBL5325600 | 0.86 | ALOX5 (1.00) | ALOX5VCPAMY1AMAPTGAA | |
| SCHEMBL2755470 | 0.85 | VCP (1.00) | ALOX5VCPHSPD1HSPE1AMY1A | |
| SCHEMBL208320 | 0.83 | VCP (0.71) | ALOX5VCPAMY1AMAPTGAA | |
| SCHEMBL4558920 | 0.83 | ALOX5 (0.71) | ALOX5VCPAMY1AMAPTGAA | |
| SCHEMBL2208135 | 0.81 | ABL1 (0.77) | ALOX5VCPMAPTGAAALDH1A1 | |
| SCHEMBL207355 | 0.81 | ALOX5 (0.68) | ALOX5VCPAMY1AMAPTGAA | |
| SCHEMBL208192 | 0.81 | ALOX5 (0.72) | ALOX5VCPAMY1AMAPTNPC1 | |
| SCHEMBL206333 | 0.80 | ALOX5 (0.77) | ALOX5VCPAMY1AMAPTGAA | |
| Bromide SCHEMBL2209661 | 0.80 | ABL1 (0.76) | ALOX5VCPMAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8088806-B2 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20070004711-A1 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | PIGS, CPT1A, SLC10A1 | ALOX5 3410/4885VCP 1270/4885HSPD1 3658/4885 |
| US-20070004711-A1 | Thiazole compounds and methods of use | PIGS, CPT1A, SLC10A1 | ALOX5 3410/4885VCP 1270/4885HSPD1 3658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.