Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 1.00 |
| ▸ | VCP | P55072 | 8/20 | 1.00 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | THRB | P10828 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26126062 | 0.92 | ALOX5 (0.85) | ALOX5VCPAMY1AMAPTALOX15 | |
| SCHEMBL205976 | 0.89 | ALOX5 (0.80) | ALOX5VCPAMY1AMAPTALOX15 | |
| SCHEMBL10246014 | 0.86 | ALOX5 (0.76) | ALOX5VCPAMY1AMAPTALOX15 | |
| SCHEMBL14825241 | 0.85 | MAPT (1.00) | ALOX5VCPAMY1AMAPTALOX15 | |
| SCHEMBL526321 | 0.85 | ALOX5 (1.00) | ALOX5VCPAMY1AMAPTALOX15 | |
| SCHEMBL26125550 | 0.85 | ALOX5 (1.00) | ALOX5VCPAMY1AMAPTALOX15 | |
| SCHEMBL12157928 | 0.84 | ALOX5 (0.73) | ALOX5VCPAMY1AMAPTALOX15 | |
| SCHEMBL31677915 | 0.84 | ALOX5 (0.73) | ALOX5VCPAMY1AMAPTALOX15 | |
| SCHEMBL2208135 | 0.84 | ABL1 (0.77) | ALOX5VCPMAPTALDH1A1GAA | |
| SCHEMBL208320 | 0.83 | VCP (0.71) | ALOX5VCPAMY1AMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007124171-A2 | COMPOSITIONS AND METHODS FOR TREATING TRINUCLEOTIDE REPEAT DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-11-01 | — | — | WO | claimed |
| WO-2007124171-A2 | COMPOSITIONS AND METHODS FOR TREATING TRINUCLEOTIDE REPEAT DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007124171-A2 | COMPOSITIONS AND METHODS FOR TREATING TRINUCLEOTIDE REPEAT DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-11-01 | — | — | WO | disclosed |