Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10247081 | 1.00 | ALDH1A1 (0.57) | ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10246997 | 0.74 | LMNA (0.62) | ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10246885 | 0.74 | TAS1R3 (0.51) | ALDH1A1TAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL10247020 | 0.74 | PYGL (0.58) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10249687 | 0.74 | TAS1R3 (0.51) | ALDH1A1TAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL10246983 | 0.73 | ALDH1A1 (0.48) | ALDH1A1TAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL10247155 | 0.73 | LMNA (0.77) | ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10249684 | 0.71 | HTT (0.62) | ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10246865 | 0.71 | LMNA (0.54) | ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10252477 | 0.71 | DHODH (0.54) | ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243335-A1 | SUBSTITUTED HYDOXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140243335-A1 | SUBSTITUTED HYDOXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140243335-A1 | SUBSTITUTED HYDOXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| WO-2012012322-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |
| US-20120015943-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACUTICALS, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015943-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACUTICALS, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015943-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC1, HDAC2 | ALDH1A1 676/4885KDM4E 668/4885TAS1R3 3594/4885 |
| US-20140243335-A1 | SUBSTITUTED HYDOXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC1, H1-3 | ALDH1A1 202/4885KDM4E 597/4885TAS1R3 3997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.