Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1022684 | 1.00 | ACHE (0.54) | ACHECA2CA1PPARGPPARD | |
| SCHEMBL29959275 | 1.00 | ACHE (0.54) | ACHECA2CA1PPARGPPARD | |
| SCHEMBL3654988 | 1.00 | ACHE (0.54) | ACHECA2CA1PPARGPPARD | |
| Bromide SCHEMBL11627374 | 0.98 | ACHE (0.53) | ACHECA2CA1PPARGPPARD | |
| Bromide SCHEMBL11628156 | 0.98 | ACHE (0.53) | ACHECA2CA1PPARGPPARD | |
| Bromide SCHEMBL11624070 | 0.98 | ACHE (0.53) | ACHECA2CA1PPARGPPARD | |
| SCHEMBL20969576 | 0.85 | SLC6A2 (0.43) | ACHECA2CA1NFKB1BLM | |
| SCHEMBL10843568 | 0.85 | ACHE (0.51) | ACHECA2CA1PPARGPPARD | |
| SCHEMBL8298141 | 0.84 | ALDH1A1 (0.60) | ACHECA2CA1PPARGPPARD | |
| SCHEMBL20969582 | 0.84 | ADRA2A (0.46) | ACHECA2CA1NFKB1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4129580-A | Resolution of certain asymmetric primary amines using lasalocid | HOFFMANN-LA ROCHE INC. (US) | 1978-12-12 | — | — | US | claimed |
| WO-2011000915-A1 | ISOFORM-SELECTIVE HCN BLOCKERS | UNIVERSITA' DEGLI STUDI DI FIRENZE (IT) | 2011-01-06 | — | — | WO | disclosed |
| US-20080064714-A1 | Novel Pyrrolodihydroisoquinolines | NYCOMED GMBH (DE) | 2008-03-13 | — | — | US | disclosed |
| EP-1838708-A2 | PYRROLODIHYDROISOQUINOLINES AS ANTIPROLIFERATIVE AGENTS | Nycomed GmbH (DE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006075012-A2 | PYRROLODIHYDROISOQUINOLINES AS ANTIPROLIFERATIVE AGENTS | NYCOMED GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
| US-4581172-A | Substituted pyrimido[6,1-a]isoquinolin-4-ones,pyrimido[6,1-a]benzozepin-4-ones and pyrimido[6,1-a]benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension | HOFFMANN-LA ROCHE INC. (US) | 1986-04-08 | — | — | US | disclosed |
| US-4129580-A | Resolution of certain asymmetric primary amines using lasalocid | HOFFMANN-LA ROCHE INC. (US) | 1978-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064714-A1 | Novel Pyrrolodihydroisoquinolines | MKI67, BAD, BAX | ACHE 4786/4885CA2 4591/4885CA1 4718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.