SCHEMBL10253234

SCHEMBL10253234

CNC(=O)/C(C#N)=C/c1cc2c3c(c1)CCCN3CCC2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ ATM Q13315 1/20 0.44
▸ KMT2A Q03164 7/20 0.41
▸ MEN1 O00255 5/20 0.41
▸ NPC1 O15118 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ CASP3 P42574 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ SENP8 Q96LD8 1/20 0.40
▸ SENP7 Q9BQF6 1/20 0.40
▸ SENP6 Q9GZR1 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ DNM1 Q05193 3/20 0.39
▸ LMNA P02545 2/20 0.38
▸ USP2 O75604 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ RAD52 P43351 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13428212 0.84 SLC16A3 (0.47) ALDH1A1KDM4EKMT2ARAD52RXFP1
SCHEMBL597887 0.84 SLC16A3 (0.47) ALDH1A1KDM4EKMT2ARAD52RXFP1
SCHEMBL14540647 0.84 SLC16A3 (0.47) ALDH1A1KDM4EKMT2ARAD52RXFP1
SCHEMBL16301917 0.83 MAPT (0.51) ALDH1A1KDM4EKMT2AMEN1MAPT
SCHEMBL23373774 0.82 ALDH1A1 (0.49) ALDH1A1KDM4EKMT2AMEN1NPC1
SCHEMBL17903535 0.82 ALDH1A1 (0.53) ALDH1A1KDM4EKMT2ADNM1LMNA
SCHEMBL23373820 0.80 KMT2A (0.46) ALDH1A1KDM4EKMT2AMEN1MAPK1
SCHEMBL24273040 0.78 KMT2A (0.45) ALDH1A1KDM4EKMT2AMEN1MAPT
SCHEMBL16301931 0.78 EGFR (0.50) ALDH1A1KDM4EKMT2AMEN1MAPT
SCHEMBL14703464 0.77 ALDH1A1 (0.50) ALDH1A1KMT2AMEN1NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2341915-B1 PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS CENTRE NAT RECH SCIENT (FR) 2019-03-20 — — EP disclosed
US-8815834-B2 Use of dendrimers to stimulate cell growth CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2014-08-26 — — US disclosed
US-20100173871-A1 PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2010-07-08 — — US disclosed
US-20100173871-A1 PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2010-07-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100173871-A1 PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS CD14, DUSP3, IRAK3 ALDH1A1 4335/4885KDM4E 4254/4885ATM 1158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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