Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025414 | 0.87 | HSD11B1 (0.41) | HSD11B1NR1H2NR1H3GRM5KDM4E | |
| SCHEMBL19953206 | 0.73 | POLB (0.38) | HTT | |
| SCHEMBL173503 | 0.71 | HSD11B1 (0.47) | DPP4SCN10AHSD11B1IGF1R | |
| SCHEMBL29520229 | 0.71 | HSD11B1 (0.47) | DPP4SCN10AHSD11B1 | |
| SCHEMBL173619 | 0.71 | HSD11B1 (0.47) | DPP4SCN10AHSD11B1 | |
| SCHEMBL20075418 | 0.71 | MAPK14 (0.44) | HTTGRM5KDM4ESMN1; SMN2 | |
| SCHEMBL8025221 | 0.71 | HTT (0.46) | HTTNR1H2NR1H3SRCKDR | |
| SCHEMBL2340641 | 0.70 | GRM5 (0.38) | GRM5SMN1; SMN2 | |
| SCHEMBL21711491 | 0.70 | SLC34A1 (0.47) | DPP4SCN10AHSD11B1GRM5CLK1 | |
| SCHEMBL6177712 | 0.70 | MAPK14 (0.65) | SRCBRAFKDRRIPK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274285-A1 | NOVEL PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127612-A1 | NOVEL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | disclosed |