Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | SLC34A1 | Q06495 | 4/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2339109 | 0.90 | GRM5 (0.39) | GRM5SLC34A1PGRNR3C2PTGS1 | |
| SCHEMBL2559888 | 0.83 | SLC34A1 (0.40) | GRM5SLC34A1PTGS1PTGS2 | |
| SCHEMBL15332993 | 0.78 | MAPK14 (0.38) | GRM5SLC34A1PGRNR3C2 | |
| SCHEMBL2555113 | 0.76 | CYP1A2 (0.37) | SLC34A1SMN1; SMN2 | |
| SCHEMBL2563022 | 0.75 | LMNA (0.41) | PTGS1PTGS2CNR1 | |
| SCHEMBL15330906 | 0.73 | HSD11B1 (0.42) | SLC34A1CNR1 | |
| SCHEMBL15330159 | 0.72 | PTGS1 (0.35) | SLC34A1PTGS1PTGS2 | |
| SCHEMBL15331398 | 0.71 | HSD11B1 (0.40) | SLC34A1SMN1; SMN2CNR1 | |
| SCHEMBL17290413 | 0.71 | HSD11B1 (0.40) | SLC34A1CNR1 | |
| SCHEMBL15330554 | 0.71 | NMT1 (0.39) | SLC34A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377953-B2 | Isothiazole and pyrazole derivatives as fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377953-B2 | Isothiazole and pyrazole derivatives as fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377953-B2 | Isothiazole and pyrazole derivatives as fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20110301034-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301034-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301034-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110224241-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110224241-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110224241-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2358699-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | Syngenta Participations AG (CH) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010069877-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| WO-2010069877-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| WO-2009007098-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224241-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | NOX3, CBR3, NOS3 | GRM5 2983/4885SLC34A1 270/4885PGR 2835/4885 |
| US-20110301034-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | ING2, IGFBP1, IP6K1 | GRM5 2369/4885SLC34A1 1027/4885PGR 2028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.