Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.46 |
| ▸ | NAMPT | P43490 | 6/20 | 0.44 |
| ▸ | LIPE | Q05469 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14596988 | 0.91 | HRH3 (0.48) | HRH3GPR119NAMPT | |
| SCHEMBL10196808 | 0.84 | TDO2 (0.48) | HRH3GPR119NAMPT | |
| SCHEMBL1372747 | 0.84 | GPR119 (0.64) | HRH3GPR119 | |
| SCHEMBL30102016 | 0.84 | GPR119 (0.64) | HRH3GPR119 | |
| SCHEMBL31003114 | 0.81 | MAPT (0.46) | HRH3GPR119NAMPT | |
| SCHEMBL17559447 | 0.77 | HRH3 (0.50) | HRH3GPR119NAMPTLIPE | |
| SCHEMBL3343638 | 0.74 | GPR119 (0.64) | HRH3GPR119 | |
| SCHEMBL5525265 | 0.74 | GPR119 (0.63) | HRH3GPR119 | |
| SCHEMBL7401143 | 0.73 | GPR119 (0.62) | HRH3GPR119 | |
| SCHEMBL8739984 | 0.73 | GPR119 (0.45) | HRH3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207168-B2 | Pyridazinone derivatives | CEPHALON, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100280007-A1 | Pyridazinone Derivatives | CEPHALON, INC. (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280007-A1 | Pyridazinone Derivatives | HRH3, HNMT, HRH4 | HRH3 1/4885GPR119 660/4885NAMPT 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.