Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29791699 | 0.88 | KCNJ5 (0.44) | KDM4EHSD11B1KCNJ5IRAK4PTGER4 | |
| SCHEMBL10280421 | 0.84 | KDM4E (0.36) | KDM4EHSD11B1KCNJ5IRAK4PTGER4 | |
| SCHEMBL24767177 | 0.78 | KDM4E (0.43) | KDM4EHSD11B1KCNJ5IRAK4EGLN2 | |
| SCHEMBL15344923 | 0.76 | PDE2A (0.44) | HSD11B1 | |
| SCHEMBL359700 | 0.75 | KDM4E (0.57) | KDM4EHSD11B1 | |
| SCHEMBL17080357 | 0.75 | PRKAB2 (0.47) | KDM4EHSD11B1KCNJ5IRAK4EGLN2 | |
| SCHEMBL31470548 | 0.75 | SMPD3 (0.44) | KDM4EHSD11B1KCNJ5IRAK4EGLN2 | |
| SCHEMBL15333581 | 0.75 | POLB (0.43) | KDM4EIRAK4 | |
| SCHEMBL24508343 | 0.74 | HSD11B1 (0.52) | KDM4EHSD11B1IRAK4 | |
| SCHEMBL18309178 | 0.74 | CYP11B2 (0.40) | KDM4EEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | HOFFMANN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20160207936-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN-LA ROCHE INC. | 2016-07-21 | — | — | US | disclosed |
| US-9255110-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | ROCHE PALO ALTO LLC (US) | 2016-02-09 | — | — | US | disclosed |
| US-20140303149-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN-LA ROCHE INC. (US) | 2014-10-09 | — | — | US | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207936-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | KDM4E 261/4885HSD11B1 2742/4885KCNJ5 2827/4885 |
| US-20140303149-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | KDM4E 261/4885HSD11B1 2742/4885KCNJ5 2827/4885 |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK4, IRAK1, IRAK2 | KDM4E 261/4885HSD11B1 2742/4885KCNJ5 2827/4885 |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | KDM4E 261/4885HSD11B1 2742/4885KCNJ5 2827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.