Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DVL1 | O14640 | 2/20 | 0.64 |
| ▸ | DVL3 | Q92997 | 2/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3078012 | 0.91 | DVL1 (0.60) | DVL1DVL3GABRA1GABRB2ALOX15 | |
| SCHEMBL10291567 | 0.88 | DVL1 (0.48) | DVL1DVL3GABRA1GABRB2ALOX15 | |
| SCHEMBL10260354 | 0.83 | DVL1 (0.64) | DVL1DVL3KDM4EALDH1A1MAPT | |
| SCHEMBL10291569 | 0.83 | DVL1 (0.44) | DVL1DVL3GABRA1GABRB2ALOX15 | |
| SCHEMBL1913466 | 0.71 | DVL1 (0.52) | DVL1DVL3GABRA1GABRB2CNR1 | |
| SCHEMBL29381538 | 0.71 | DVL1 (0.52) | DVL1DVL3GABRA1GABRB2CNR1 | |
| SCHEMBL28649784 | 0.68 | MEN1 (0.47) | DVL1DVL3KDM4EMEN1KMT2A | |
| SCHEMBL16672568 | 0.67 | HTT (0.50) | KDM4EMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL7381366 | 0.67 | HTR6 (0.74) | ALOX15KDM4EMCL1ALDH1A1MAPT | |
| SCHEMBL28658878 | 0.66 | L3MBTL1 (0.47) | DVL1DVL3EGFRKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211934-B2 | Small molecule inhibition of PDZ-domain interaction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-03 | — | — | US | disclosed |
| US-20110160263-A1 | Small molecule inhibition of PDZ-domain interaction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2011-06-30 | — | — | US | disclosed |
| US-7795295-B2 | Small molecule inhibition of PDZ-domain interaction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-09-14 | — | — | US | disclosed |
| US-20080064733-A1 | Small Molecule Inhibition of Pdz-Domain Interaction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064733-A1 | Small Molecule Inhibition of Pdz-Domain Interaction | DVL1, DVL3, PDLIM5 | DVL1 1/4885DVL3 2/4885GABRA1 4622/4885 |
| US-20110160263-A1 | Small molecule inhibition of PDZ-domain interaction | DVL1, DVL3, PDLIM5 | DVL1 1/4885DVL3 2/4885GABRA1 4563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.