Sugi Predict

Sugi Predict / Targets / DVL3

DVL3

Segment polarity protein dishevelled homolog DVL-3 · Q92997 · DVL3 on Sugi Atlas →

95 patent compounds predicted against DVL3, 43 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL3078012 SCHEMBL3078012 0.60 3/20
SCHEMBL1913466 SCHEMBL1913466 0.52 3/20
SCHEMBL4251120 SCHEMBL4251120 0.52 3/20
SCHEMBL29381538 SCHEMBL29381538 0.52 3/20
SCHEMBL29754378 SCHEMBL29754378 0.47 3/20
SCHEMBL10260354 SCHEMBL10260354 0.64 2/20
SCHEMBL10260434 SCHEMBL10260434 0.64 2/20
SCHEMBL15506804 SCHEMBL15506804 0.49 2/20
SCHEMBL10779581 SCHEMBL10779581 0.45 2/20
SCHEMBL4213492 SCHEMBL4213492 0.45 2/20
SCHEMBL10780432 SCHEMBL10780432 0.44 2/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL10784337) 0.44 2/20
SCHEMBL27343649 SCHEMBL27343649 0.44 2/20
Isopropyl Alcohol Isopropyl Alcohol (SCHEMBL11011590) 0.42 2/20
SCHEMBL20794421 SCHEMBL20794421 0.42 2/20
SCHEMBL13754925 SCHEMBL13754925 0.42 2/20
SCHEMBL20794764 SCHEMBL20794764 0.41 2/20
SCHEMBL12826058 SCHEMBL12826058 0.38 2/20
SCHEMBL7965110 SCHEMBL7965110 0.52 1/20
SCHEMBL15506889 SCHEMBL15506889 0.49 1/20

Clinical trials — most relevant to DVL3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment PHASE2/PHASE3RECRUITING
NG2 and DLL3 CAR-T Cells Targeting Melanoma PHASE1/PHASE2RECRUITING
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma PHASE2RECRUITING
FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma PHASE1COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) PHASE1COMPLETED
Klotho _ LRP-6 _ Gastric Adenocarcinoma nanUNKNOWN
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study nanCOMPLETED
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins nanCOMPLETED
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma. nanRECRUITING
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact nanUNKNOWN
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury nanUNKNOWN
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs nanCOMPLETED
Genetic Basis of Non Syndromic Congenital Diaphragmatic Hernia nanCOMPLETED
CDH1 Germline Mutations in Lobular Breast Cancer nanCOMPLETED
Mapping Disease Pathways for Biliary Atresia nanRECRUITING
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies nanRECRUITING
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science nanRECRUITING
SS-HH-OCT as a Novel Diagnostic Modality for Early-Onset Retinal Dystrophies (EORDs) nanRECRUITING
Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors nanNO_LONGER_AVAILABLE
Genetic Variants of Selected Genes in Colo-Rectal Cancer Patients. nanUNKNOWN
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia nanUNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan nanENROLLING_BY_INVITATION
Studying the Role of Circulating Tumor Cell Clusters in Patients With High-risk Early Breast Cancer, Study GALIA nanRECRUITING
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy nanCOMPLETED
Clinical Utility of Pediatric Whole Exome Sequencing nanCOMPLETED
Genetics of Primary Ciliary Dyskinesia nanCOMPLETED
The Activation of Hippo Pathway in Nasal Polyps nanUNKNOWN
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls. nanUNKNOWN
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DVL3 binder may also engage these)

ProteinNameSimilarity
Q61062 — 1.000 Q61062 →
B1WAP7 — 1.000 B1WAP7 →
Q9WVB9 — 0.999 Q9WVB9 →
P54792 — 0.998 P54792 →
Q05AS8 — 0.997 Q05AS8 →
P51141 — 0.997 P51141 →
Q6DKE2 — 0.995 Q6DKE2 →
Q5IS48 — 0.995 Q5IS48 →
DVL1 Segment polarity protein dishevelled homolog DVL-1 0.995 landscape →
P51142 — 0.992 P51142 →
Q60838 — 0.990 Q60838 →
O14641 — 0.990 O14641 →
Q95168 — 0.989 Q95168 →
Q9UQB3 — 0.989 Q9UQB3 →
Q9UDY2 — 0.987 Q9UDY2 →
P39447 — 0.987 P39447 →
Q9Z0U1 — 0.986 Q9Z0U1 →
Q80W04 — 0.985 Q80W04 →
Q6NRE7 — 0.984 Q6NRE7 →
A0A0G2K2P5 — 0.984 A0A0G2K2P5 →
Q9Y2L6 — 0.983 Q9Y2L6 →
Q4VGL6 — 0.983 Q4VGL6 →
CTNND1 Catenin delta-1 0.982 landscape →
Q66IV1 — 0.982 Q66IV1 →
Q07157 — 0.982 Q07157 →
Q9UPY6 — 0.982 Q9UPY6 →
Q8K4S7 — 0.981 Q8K4S7 →
PTPN14 Tyrosine-protein phosphatase non-receptor type 14 0.981 landscape →
Q6NUC6 — 0.981 Q6NUC6 →
Q7PQ25 — 0.981 Q7PQ25 →